Protein Alignment Ugt37A3 and UGT8

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_003351.3
• Gene: UGT8 / 7368
• HGNCID: 12555
• Length: 541
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 147/554 - (26%)
• Similarity: 265/554 - (47%)
• Gaps: 83/554 - (14%)

  Fly     8 FLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHN-VTVVTVLKPVV--NHK 69
            |:||..|:|.    ::.|.|:.:.|.:..||:.|..:.|..|.|.||: |.:::..:.:.  ||.
Human     8 FILLWSAVGI----AKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHY 68

  Fly    70 NITVIQVPLSKEEAQQMSDTIGAMSKNDNSNM---ALSLLRMSDQMDFMIRKNAETLMNDRVRDL 131
            :       |.:......|.|..|..::...|:   .|:.:.:.|.:|. ..||.:.::.:.....
Human    69 S-------LQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDH-YTKNCDLMVGNHALIQ 125

  Fly   132 YLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYA----GISN 192
            .|.: .||||::                         :.||.:...:|.:.|.|.||    |:..
Human   126 GLKK-EKFDLLL-------------------------VDPNDMCGFVIAHLLGVKYAVFSTGLWY 164

  Fly   193 PAE-GSKA-----------VTFQRRLSSYMQSLGFGVFSHLS---------ERRNRNWYKEVYGN 236
            ||| |:.|           :|.:..|...|::.|..:.|.|.         ||     ..:.|..
Human   165 PAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYER-----IMQKYNL 224

  Fly   237 DPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATD- 300
            .|:...| :::..:||....:..|.|.| ||.:|:.:.:|||..| ...|||:::..::..|.:
Human   225 LPEKSMY-DLVHGSSLWMLCTDVALEFP-RPTLPNVVYVGGILTK-PASPLPEDLQRWVNGANEH 286

  Fly   301 GAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWE-DQENTPGKSANILYSKWLPQDDIL 364
            |.:|:|.|:.|  |:|:.|...|:...|.:|.::|||::. .:....|.:..::  :||||:|:|
Human   287 GFVLVSFGAGV--KYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLI--EWLPQNDLL 347

  Fly   365 AHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEA 429
            .|..||.|::|.|...|.|:.|||.|::.:|:|.|.......:...|.|:.|...|:.||...||
Human   348 GHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEA 412

  Fly   430 ILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDI 494
            ::::::||.|.:|.:..|.:::|:|.......:||.:|:|||:||.||::.:..:||.....:||
Human   413 LVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDI 477

  Fly   495 CFLIFVILVSVLVLIKFLVQFIYRRFISKPKKEK 528
            .|::.:....:..|:.::.:||||:..|...:.|
Human   478 AFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNK 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	120/471 (25%)
UGT8	NP_003351.3	Glycosyltransferase_GTB-type	21..502	CDD:471961	139/526 (26%)