Protein Alignment Ugt37A3 and UGT2B17

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 140/545 - (25%)
• Similarity: 265/545 - (48%)
• Gaps: 49/545 - (8%)

  Fly     8 FLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNIT 72
            |||:.::  ....|.....:| ::|: ..||.|...:..:.|.:.||.|.|:|         :..
Human     9 FLLMQLS--CYFSSGSCGKVL-VWPT-EYSHWINMKTILEELVQRGHEVIVLT---------SSA 60

  Fly    73 VIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDL---YLN 134
            .|.|..||..|.::.....:::|||..:.   .::|.|:..:.|.||.......::::|   |.:
Human    61 SILVNASKSSAIKLEVYPTSLTKNDLEDF---FMKMFDRWTYSISKNTFWSYFSQLQELCWEYSD 122

  Fly   135 RGNKF--DLVISGYFM-----NDFQLGFARKVNAPVIVLA---TMPPNHLLNPLIGNPLEVSYAG 189
            ...|.  |.|::...|     :.|.:..|..||....:||   .:|..:.|...:|..:|.:..|
Human   123 YNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGG 187

  Fly   190 ISNP--------AEGSKAVTFQRRLSSYMQSLGFGV-FSHLSERRNRNWYKEVYGNDPKMPEYSE 245
            ...|        :|.|..:.|..|:.:.:..|.|.. |.....::...:|.||.|....:   .|
Human   188 FLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTL---FE 249

  Fly   246 MLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGS 309
            .:....:....::...|.| ||.:|:...:||:..| ...|||:.:.||: .:..:|.::.||||
Human   250 TMGKAEMWLIRTYWDFEFP-RPFLPNVDFVGGLHCK-PAKPLPKEMEEFVQSSGENGIVVFSLGS 312

  Fly   310 NVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQE-NTPGKSANILYSKWLPQDDILAHPNIKLFI 373
            .:  .:::.::...:.:.|:::.::|:|:::.:: ||.|.:.. || |||||:|:|.||..|.||
Human   313 MI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTR-LY-KWLPQNDLLGHPKTKAFI 373

  Fly   374 NHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQ 438
            .|.|..||.|:.|||.||:.:|:||||..|...|...|..|::.:.|:..:....|:..::::|.
Human   374 THGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPI 438

  Fly   439 YAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILV 503
            |.|.:...|.::.|:|:...:..::|.|:|:||.||.||:....::::|..:::|:...:...:.
Human   439 YKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVA 503

  Fly   504 SVLVLIKFLVQFIYRRFISKPKKEK 528
            :::.:|.....|.:|:.....||:|
Human   504 TMIFMITKCCLFCFRKLAKTGKKKK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	119/462 (26%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	132/516 (26%)