DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and UGT2B10

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001066.1	Gene:	UGT2B10 / 7365	HGNCID:	12544	Length:	528	Species:	Homo sapiens

Alignment Length:	519	Identity:	133/519 - (25%)
Similarity:	235/519 - (45%)	Gaps:	72/519 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KVLAENGHNVTVVTVLKPVV---NHKNITVIQV-PLSKEEAQQMSDTIGAMSKNDNSNMALSLL- 106
            |.|.:.||.|||:.....::   |..:...::| |.|             ::|.:..|:.:.|:
Human    43 KELVQRGHEVTVLASSASILFDPNDSSTLKLEVYPTS-------------LTKTEFENIIMQLVK 94

  Fly   107 RMSD-QMD-----FMIRKNAETLMNDRVR----DLYLNR-------GNKFDLVISGYFMNDFQLG 154
            |:|: |.|     |...:.....:||.:|    |:..|:       .::||:|.:..::...:|
Human    95 RLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGEL- 158

  Fly   155 FARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNP--------AEGSKAVTFQRRLSSYMQ 211
            .|...|.|.:.      :|..:|  |...|....|...|        ::.|..:||..|:.:.:.
Human   159 LAELFNIPFVY------SHSFSP--GYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLY 215

  Fly   212 SLGFGV-FSHLSERRNRNWYKEVYGNDPKMPEYSE----MLKNTSLVFFSSHAASEGPIRPNVPS 271
            .|.|.. |...:.::...:|.||.|....:.|...    .|...|..|...|     |..|||..
Human   216 VLYFDFWFQIFNMKKWDQFYSEVLGRPTTLSETMRKADIWLMRNSWNFKFPH-----PFLPNVDF 275

  Fly   272 AIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERV 335
               :||:..| ...|||:.:.||: .:..:|.::.||||.|  .::..:....:...|:|:.::|
Human   276 ---VGGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSMV--SNMTEERANVIATALAKIPQKV 334

  Fly   336 IWKWEDQENTP-GKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFAD 399
            :|:::.  |.| ....|....||:||:|:|.||..:.||.|.|..||.|:.|||.||:.:|:|.|
Human   335 LWRFDG--NKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFD 397

  Fly   400 QPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYW 464
            ||.|...|...|..:.:...|:.......|:..::::|.|.|.:...|.:..|:|:...:..::|
Human   398 QPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFW 462

  Fly   465 TEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRFISKPKKEK 528
            .|:|:||.||.||:....::::...:::|:...:...:.:||.:|.....|.:.:|..|.||.|
Human   463 IEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	123/479 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	130/515 (25%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	130/515 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840