Protein Alignment Ugt37A3 and UGT2B10

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 133/519 - (25%)
• Similarity: 235/519 - (45%)
• Gaps: 72/519 - (13%)

  Fly    47 KVLAENGHNVTVVTVLKPVV---NHKNITVIQV-PLSKEEAQQMSDTIGAMSKNDNSNMALSLL- 106
            |.|.:.||.|||:.....::   |..:...::| |.|             ::|.:..|:.:.|:
Human    43 KELVQRGHEVTVLASSASILFDPNDSSTLKLEVYPTS-------------LTKTEFENIIMQLVK 94

  Fly   107 RMSD-QMD-----FMIRKNAETLMNDRVR----DLYLNR-------GNKFDLVISGYFMNDFQLG 154
            |:|: |.|     |...:.....:||.:|    |:..|:       .::||:|.:..::...:|
Human    95 RLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGEL- 158

  Fly   155 FARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNP--------AEGSKAVTFQRRLSSYMQ 211
            .|...|.|.:.      :|..:|  |...|....|...|        ::.|..:||..|:.:.:.
Human   159 LAELFNIPFVY------SHSFSP--GYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLY 215

  Fly   212 SLGFGV-FSHLSERRNRNWYKEVYGNDPKMPEYSE----MLKNTSLVFFSSHAASEGPIRPNVPS 271
            .|.|.. |...:.::...:|.||.|....:.|...    .|...|..|...|     |..|||..
Human   216 VLYFDFWFQIFNMKKWDQFYSEVLGRPTTLSETMRKADIWLMRNSWNFKFPH-----PFLPNVDF 275

  Fly   272 AIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERV 335
               :||:..| ...|||:.:.||: .:..:|.::.||||.|  .::..:....:...|:|:.::|
Human   276 ---VGGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSMV--SNMTEERANVIATALAKIPQKV 334

  Fly   336 IWKWEDQENTP-GKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFAD 399
            :|:::.  |.| ....|....||:||:|:|.||..:.||.|.|..||.|:.|||.||:.:|:|.|
Human   335 LWRFDG--NKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFD 397

  Fly   400 QPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYW 464
            ||.|...|...|..:.:...|:.......|:..::::|.|.|.:...|.:..|:|:...:..::|
Human   398 QPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFW 462

  Fly   465 TEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRFISKPKKEK 528
            .|:|:||.||.||:....::::...:::|:...:...:.:||.:|.....|.:.:|..|.||.|
Human   463 IEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	114/453 (25%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	130/515 (25%)