Protein Alignment Ugt37A3 and UGT2B4

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 136/544 - (25%)
• Similarity: 256/544 - (47%)
• Gaps: 51/544 - (9%)

  Fly    10 LLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKN---- 70
            ||.|.:.....|.....:| ::|: ..||.:...:....|.:.||.|||:.....:....|
Human     9 LLLIQLSCYFSSGSCGKVL-VWPT-EFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPST 71

  Fly    71 --ITVIQVPLSKEE----AQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDR-- 127
              ..|..|.|:|.|    .:|:......:.|:...:....:..:....:.::||..:.:::::
Human    72 LKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKL 136

  Fly   128 VRDLYLNRGNKFDLVISGYFMNDFQLG--FARKVNAPVIVLATMPPNHLLNPLIGNPL-EVSYAG 189
            ::.|   :.::||:|::...   |..|  .|..:..|.:......|.:.:....|..| ..||..
Human   137 MKKL---QESRFDVVLADAV---FPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVP 195

  Fly   190 ISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNW---YKEVYGNDPKMPEYSEMLKNTS 251
            :. .:|.|..:||..|:.:.:..|.|..:..:.:.  :.|   |.||.|....:   ||.:....
Human   196 VV-MSELSDQMTFIERVKNMIYVLYFEFWFQIFDM--KKWDQFYSEVLGRPTTL---SETMAKAD 254

  Fly   252 LVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKH 315
            :....::...:.| .|.:|:...:||:..| ...|||:.:.||: .:..:|.::.||||.|.
Human   255 IWLIRNYWDFQFP-HPLLPNVEFVGGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSMVS--- 314

  Fly   316 LNPDTVAKMFNV----LSKLKERVIWKWE-DQENTPGKSANILYSKWLPQDDILAHPNIKLFINH 375
               :|..:..||    |:|:.::|:|::: ::.:|.|.:.. || ||:||:|:|.||..:.||.|
Human   315 ---NTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTR-LY-KWIPQNDLLGHPKTRAFITH 374

  Fly   376 AGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYA 440
            .|..||.|:.|||.||:.:|:|||||.|...|...|..::|...|:.......|:..::::|.|.
Human   375 GGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYK 439

  Fly   441 ERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIC-FLIFVILVS 504
            |.....|.::.|:|:...:..::|.|:|:||.||.||:.....:::...:::|:. ||:..:...
Human   440 ENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATV 504

  Fly   505 VLVLIKFLVQFIYRRFISKPKKEK 528
            :.::.|.|  |...:|:...||.|
Human   505 IFIITKCL--FCVWKFVRTGKKGK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	126/503 (25%)
		UDPGT	37..526	CDD:278624	127/513 (25%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	130/526 (25%)
		UDPGT	24..524	CDD:278624	129/525 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840