Protein Alignment Ugt37A3 and Ugt1a8

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001365304.1
• Gene: Ugt1a8 / 613123
• MGIID: 3576090
• Length: 530
• Species: Mus musculus
• Alignment Length: 562
• Identity: 152/562 - (27%)
• Similarity: 258/562 - (45%)
• Gaps: 81/562 - (14%)

  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVN-----H 68
            |.|.:.:....|.:|...:| :.| :..||........:.|:..||.|.||.   |.|:     .
Mouse    10 LPLRVCLLLAFGLAQAGRLL-VVP-MDGSHWFSMKMIVEKLSHRGHEVVVVI---PEVSWHLGKS 69

  Fly    69 KNITVIQVPLSKEEAQQMSDTIGAMSKN---------DNSNMAL-SLLRMSDQMDFMIR-KNAET 122
            :|.||        :...:|.|:..:|.:         :|..:.: |||:.|.:..|.:. .:..:
Mouse    70 QNFTV--------KTYSVSYTLEDLSHHFNFFAHKQWENREVGMFSLLKHSGKGFFQVLFSHCRS 126

  Fly   123 LMNDRVRDLYLNRGNKFDLVISGYFMNDFQ---LGFARKVNAPVIVLATMPPNHLLNPLIGNPLE 184
            |.||:....||.: ..||.|    |::.|.   |..|:..:.|.:|.:.....|.|:.....|..
Mouse   127 LFNDKKLVEYLKQ-RSFDAV----FLDPFDVCGLTIAKYFSLPSVVFSGGIFCHYLDEGAQCPSP 186

  Fly   185 VSYAGISNPAEGSK---AVTFQRRLSSYMQSLGFGVFSHLSERRNRNWY--------KEVYGNDP 238
            .||.    |...||   .:||:.|:.:|        ||::.||....::        .||.....
Mouse   187 PSYV----PRILSKFADTMTFKERVWNY--------FSYMKERAFCPYFFKTAIEIASEVLQTPV 239

  Fly   239 KMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--DG 301
            .|   :::..:.|:..|.:....|.| ||.:|:.:.||||.. ....||.:....:: ||:  .|
Mouse   240 TM---TDLFSSVSIWMFRTDFVLEFP-RPVMPNMVYIGGINC-HPGKPLSKEFEAYV-NASGEHG 298

  Fly   302 AILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDDILA 365
            .::.||||.|  ..:......::...|.::.:.|:|::..  ..|...| |.:..|||||:|:|.
Mouse   299 IVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLLG 359

  Fly   366 HPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAI 430
            ||..:.||.|:|..||.|...:|.||:.:|:|.||..||..|...|.|:||::|.:.....:.|:
Mouse   360 HPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENAL 424

  Fly   431 LEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDI 494
            ..:::|..|.|.:...|:|::|||:...:..::|.|||:||.||.||: |..| :::...:::|:
Mouse   425 KTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDV 488

  Fly   495 C-FLIFVILVSVLVLIKFLVQFIYRRF-----ISKPKKEKTH 530
            . ||:.::|..|.::.|.......:.|     :.|..|.|||
Mouse   489 IGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	124/471 (26%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	143/535 (27%)