Protein Alignment Ugt37A3 and UGT2A2

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 132/540 - (24%)
• Similarity: 249/540 - (46%)
• Gaps: 71/540 - (13%)

  Fly    26 NILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVV----TVL------KPVVNHKNITVIQVPLSK 80
            |:| ::|:.....|.|::...:::..| |||||:    |:.      .||    |..||.|...|
Human    31 NVL-IWPTDGSHWLNIKIILEELIQRN-HNVTVLASSATLFINSNPDSPV----NFEVIPVSYKK 89

  Fly    81 EEAQQMSD--------------TIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDL 131
            .....:.:              ||.|..| :...:..:..:::.|:...:.||.:.:..
Human    90 SNIDSLIEHMIMLWIDHRPTPLTIWAFYK-ELGKLLDTFFQINIQLCDGVLKNPKLMAR------ 147

  Fly   132 YLNRGNKFDLVISG--YFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGN-PLEVSYAGISNP 193
             |.:|. ||::::.  ....|.   .|.|:..|.:......|...:....|. |..|||.    |
Human   148 -LQKGG-FDVLVADPVTICGDL---VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYV----P 203

  Fly   194 A---EGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNW---YKEVYGNDPKMPEYSEMLKNTSL 252
            |   |.:..:||..|:.:   ::.:.:..::.:.....|   |.::.|....:   .|.:....:
Human   204 AALSELTDQMTFGERIKN---TISYSLQDYIFQSYWGEWNSYYSKILGRPTTL---CETMGKAEI 262

  Fly   253 VFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKHL 316
            ....::...|.| ||.:|:...:||:..| ...|||:.:.||: .:..:|.::.||||.|  |:|
Human   263 WLIRTYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNL 323

  Fly   317 NPDTVAKMFNVLSKLKERVIWKWEDQE-NTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGG 380
            ..:....:.:.|:::.::|:|:::.:: .|.|.:..:.  .|:||:|:|.||..|.||.|.|..|
Human   324 TEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNG 386

  Fly   381 ITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKS 445
            |.|:.|||.||:.:|:|||||.|...|...|..:.::|.|:.......|:..:::.|.|.|....
Human   387 IYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMR 451

  Fly   446 FSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIK 510
            .|.::.|:|:...:..::|.|:|:||.||.||:.....:::...:::|:...:.|.:.:.:.|:.
Human   452 LSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVI 516

  Fly   511 FLVQFIYRRF--ISKPKKEK 528
            ....|..::|  |.|.||.:
Human   517 QCCLFSCQKFGKIGKKKKRE 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	114/472 (24%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	127/526 (24%)