Protein Alignment Ugt37A3 and UGT2A2

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 132/539 - (24%)
• Similarity: 250/539 - (46%)
• Gaps: 69/539 - (12%)

  Fly    26 NILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVV----TVL------KPVVNHKNITVIQVPLSK 80
            |:| ::|:.....|.|::...:::..| |||||:    |:.      .||    |..||.|...|
Human    31 NVL-IWPTDGSHWLNIKIILEELIQRN-HNVTVLASSATLFINSNPDSPV----NFEVIPVSYKK 89

  Fly    81 EEAQQMSD--------------TIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDL 131
            .....:.:              ||.|..| :...:..:..:::.|:...:.||.:.:..
Human    90 SNIDSLIEHMIMLWIDHRPTPLTIWAFYK-ELGKLLDTFFQINIQLCDGVLKNPKLMAR------ 147

  Fly   132 YLNRGNKFDLVISG--YFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGN-PLEVSY--AGIS 191
             |.:|. ||::::.  ....|.   .|.|:..|.:......|...:....|. |..|||  |.:|
Human   148 -LQKGG-FDVLVADPVTICGDL---VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALS 207

  Fly   192 NPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNW---YKEVYGNDPKMPEYSEMLKNTSLV 253
               |.:..:||..|:.:   ::.:.:..::.:.....|   |.::.|....:   .|.:....:.
Human   208 ---ELTDQMTFGERIKN---TISYSLQDYIFQSYWGEWNSYYSKILGRPTTL---CETMGKAEIW 263

  Fly   254 FFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKHLN 317
            ...::...|.| ||.:|:...:||:..| ...|||:.:.||: .:..:|.::.||||.|  |:|.
Human   264 LIRTYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLT 324

  Fly   318 PDTVAKMFNVLSKLKERVIWKWEDQE-NTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGI 381
            .:....:.:.|:::.::|:|:::.:: .|.|.:..:.  .|:||:|:|.||..|.||.|.|..||
Human   325 EEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNGI 387

  Fly   382 TESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSF 446
            .|:.|||.||:.:|:|||||.|...|...|..:.::|.|:.......|:..:::.|.|.|.....
Human   388 YEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRL 452

  Fly   447 STLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKF 511
            |.::.|:|:...:..::|.|:|:||.||.||:.....:::...:::|:...:.|.:.:.:.|:..
Human   453 SRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQ 517

  Fly   512 LVQFIYRRF--ISKPKKEK 528
            ...|..::|  |.|.||.:
Human   518 CCLFSCQKFGKIGKKKKRE 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	123/497 (25%)
		UDPGT	37..526	CDD:278624	127/524 (24%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	127/525 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840