DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	145/550 - (26%)
Similarity:	243/550 - (44%)	Gaps:	82/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTV----VTVLKPVVNHKNITVIQVPLSKEE 82
            ::|..:| :|| :..||.:......:.|...||...|    |||.....:...:....||.:::.
  Rat    23 AEGGKVL-VFP-MEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQTYPVPYTRQG 85

  Fly    83 -AQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLN-------RGNKF 139
             .|||...|..:.  :..|...:.|..|:     |.||..|::.....:|..|       ..:.|
  Rat    86 FRQQMMRNIKVVF--ETGNYVKTFLETSE-----ILKNISTVLLRSCMNLLHNGSLLQHLNSSSF 143

  Fly   140 DLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNP----LEVSYAGISNPAEG---- 196
            |:|::.                |||     |...:|...:|.|    |.....||.:.|..
  Rat   144 DMVLTD----------------PVI-----PCGAVLAKYLGIPTVFFLRYIPCGIDSEATQCPKP 187

  Fly   197 -----------SKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNT 250
                       |..:||.:|:.:.:..|......|.|..|..:...|:...:..:   .|:|.:.
  Rat   188 SSYIPNLLTMLSDHMTFLQRVKNMLYPLALKYICHFSFTRYESLASELLQREVSL---VEVLSHA 249

  Fly   251 SLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--DGAILLSLGSNVQG 313
            |:..|......:.| ||.:|:.:.||||....| .||.|....:: ||:  .|.::.||||.|
  Rat   250 SVWLFRGDFVFDYP-RPVMPNMVFIGGINCVIK-KPLSQEFEAYV-NASGEHGIVVFSLGSMV-- 309

  Fly   314 KHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDDILAHPNIKLFINHAG 377
            ..:......::...|.::.:.|:|::..  ..|...| |.:..|||||:|:|.||..:.||.|:|
  Rat   310 SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSG 372

  Fly   378 KGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAER 442
            ..||.|...:|.||:.:|:|.||..||..|...|.|:||::|.:.....:.|:..:::|..|.|.
  Rat   373 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 437

  Fly   443 VKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIC-FLIFVILVSV 505
            :...|:|::|||:...:..::|.|||:||.||.||: |..| :::...:::|:. ||:.::|..|
  Rat   438 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVV 501

  Fly   506 LVLIKFLVQFIYRRF-----ISKPKKEKTH 530
            .::.|.......:.|     :.|..|.|||
  Rat   502 FIVYKSCAYGCRKCFGGKGRVKKSHKSKTH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	133/502 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	137/529 (26%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	139/536 (26%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	83/253 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.890