DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A3 and ugt8

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	566	Identity:	144/566 - (25%)
Similarity:	252/566 - (44%)	Gaps:	89/566 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VEKFLLLAIAIGAVMGS-SQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLK----P 64
            ::.|.:||..:..:..| |..|.|:.:.|.:..|||.|..:.|..|...||: ||..|.:    |
Zfish     1 MKAFFVLATLLWCLATSLSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHD-TVFLVSEGREIP 64

  Fly    65 VVNHKNITVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVR 129
            ..||..:            |:......:.|.:|                         .:..:||
Zfish    65 PSNHYRL------------QRYPGIFNSTSADD-------------------------FLQSKVR 92

  Fly   130 DLYLNRGNKFDL--VISGYFMN-DFQLG---FARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYA 188
            :::..|....:|  ::..|..| |..:|   ...::......|..:.||.:...:|.:.|.|.||
Zfish    93 NIFSGRLTALELFDILDHYSQNCDAVVGSTSVMEQLKREHFDLLLVDPNEMCGFVIAHILGVQYA 157

  Fly   189 ----GISNPAE-GSKA----------------VTFQR--RLSSYMQSLGFGVFSHLSERRNRNWY 230
                |:..||| |:.|                ..|||  ..:.|:.| .|||...:..:.:|...
Zfish   158 VFSTGLWYPAEVGAPAPLSYVPEFNSLLTDHMSLFQRVANTAVYLVS-RFGVQFLVLPKYDRIMR 221

  Fly   231 KEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL 295
            |  |...|.:..: ::::|:.|....:..|.|.| ||.:|..:.:|||..| .|.||||....::
Zfish   222 K--YNIQPSVSMH-DLVQNSRLWMLCTDMALEFP-RPTLPHVVYVGGILTK-PPSPLPQEFETWV 281

  Fly   296 GNA-TDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWED-QENTPGKSANILYSKWL 358
            .:. .||.:::|.|:.|  |:|:.|...|:...||:|.:||||::.. ..:..|.:..::  .|:
Zfish   282 KDTDEDGFVVVSFGAGV--KYLSDDIAQKLAGALSRLPQRVIWRFSGVPPSNLGNNTKLV--DWM 342

  Fly   359 PQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEE 423
            ||:|:|...|.:.|::|.|...|.|:.|||.|::.:|:|.|.......:...|.|:.|....:.|
Zfish   343 PQNDLLGQTNTRAFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSE 407

  Fly   424 KPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIA 488
            :....|::.::::.:|.||.:..|.:::|:|.......:||..|::||.||.||:|.:..:....
Zfish   408 EDLYTAMVNVITDKRYRERAQLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQ 472

  Fly   489 ANNIDICFLIFVILV----SVLVLIKFLVQFIYRRFISKPKKEKTH 530
            ...:|:..:|.|.|:    .:..::|| :||...|..|..:|...|
Zfish   473 YFLLDVAMVIGVCLLLTGYCLYRIVKF-IQFRLGRGSSPGEKVNGH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	132/520 (25%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	134/527 (25%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	133/526 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840