Protein Alignment Ugt37A3 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 140/562 - (24%)
• Similarity: 251/562 - (44%)
• Gaps: 85/562 - (15%)

  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVN----HK 69
            |||::...|..|..       |...:..||.:......:.|...||...|:|   |.||    .:
Human    18 LLLSVQPWAESGKV-------LVVPIDGSHWLSMREVLRELHARGHQAVVLT---PEVNMHIKEE 72

  Fly    70 N---ITVIQVPLSKEE--------AQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETL 123
            |   :|...:..:::|        .|...:|...:.|...|      :.|.:.|..:..::...|
Human    73 NFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRS------MAMLNNMSLVYHRSCVEL 131

  Fly   124 MNDRVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLI----GNPLE 184
            :::.....:|| ...||:|::.                ||.:.|.:...:|..|.:    ..|.:
Human   132 LHNEALIRHLN-ATSFDVVLTD----------------PVNLCAAVLAKYLSIPTVFFLRNIPCD 179

  Fly   185 VSYAGIS--NPAE--------GSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPK 239
            :.:.|..  ||:.        .|..:||.:|:.:.:..|......|.......:...|::..:..
Human   180 LDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVS 244

  Fly   240 MPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--DGA 302
            :   .::|.:.|:..|......:.| ||.:|:.:.||||...:: .||.|....:: ||:  .|.
Human   245 V---VDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANR-KPLSQEFEAYI-NASGEHGI 303

  Fly   303 ILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDDILAH 366
            ::.||||.|  ..:.......:.:.|.|:.:.|:|::..  ..|...| |.:..|||||:|:|.|
Human   304 VVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGH 364

  Fly   367 PNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAIL 431
            |..:.||.|||..|:.||..:|.||:.:|:|.||..||..|...|.|:||::|.:..:..:.|:.
Human   365 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALK 429

  Fly   432 EILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIC 495
            .::::..|.|.:...|:|::|||:...:..::|.|:|:||.||.||: |..| :::...:::|:.
Human   430 AVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVI 493

  Fly   496 -FLIFVILVSVLVLIKFLVQFIYRRF------ISKPKKEKTH 530
             ||:.|:|....:..| ...:.||:.      :.|..|.|||
Human   494 GFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKKAHKSKTH 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	127/513 (25%)
		UDPGT	37..526	CDD:278624	130/528 (25%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	131/540 (24%)
		egt	<262..508	CDD:223071	82/253 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840