Protein Alignment Ugt37A3 and UGT1A1

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 146/558 - (26%)
• Similarity: 261/558 - (46%)
• Gaps: 76/558 - (13%)

  Fly    10 LLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVN------- 67
            ||...:|.|:  |....|| |.| :..||.:..:.|.:.|.:.||.   :.||.|..:
Human    15 LLLCVLGPVV--SHAGKIL-LIP-VDGSHWLSMLGAIQQLQQRGHE---IVVLAPDASLYIRDGA 72

  Fly    68 HKNITVIQVPLSKEEAQQMSDTIG-AMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDL 131
            ...:....||..:|:.::...::| .:.:||      |.|:...:....|:|::..|::.....|
Human    73 FYTLKTYPVPFQREDVKESFVSLGHNVFEND------SFLQRVIKTYKKIKKDSAMLLSGCSHLL 131

  Fly   132 YLNRGNK----------FDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVS 186
            :    ||          ||::::..|:....: .|:.::.|.:......|..|.......|...|
Human   132 H----NKELMASLAESSFDVMLTDPFLPCSPI-VAQYLSLPTVFFLHALPCSLEFEATQCPNPFS 191

  Fly   187 YAGISNP-AEGSKAVTFQRRLSSYMQSLGFG-------VFSHLSERRNRNWYKEVYGNDPKMPEY 243
            |  :..| :..|..:||.:|:.:.:  :.|.       |:|..:...:....:||...|
Human   192 Y--VPRPLSSHSDHMTFLQRVKNML--IAFSQNFLCDVVYSPYATLASEFLQREVTVQD------ 246

  Fly   244 SEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--DGAILLS 306
              :|.:.|:..|.|....:.| ||.:|:.:.:|||....: :||.|....:: ||:  .|.::.|
Human   247 --LLSSASVWLFRSDFVKDYP-RPIMPNMVFVGGINCLHQ-NPLSQEFEAYI-NASGEHGIVVFS 306

  Fly   307 LGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDDILAHPNIK 370
            |||.|  ..:.......:.:.|.|:.:.|:|::..  ..|...| |.:..|||||:|:|.||..:
Human   307 LGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTR 367

  Fly   371 LFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILS 435
            .||.|||..|:.||..:|.||:.:|:|.||..||..|...|.|:||::|.:..:..:.|:..:::
Human   368 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 432

  Fly   436 NPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIC-FLI 498
            :..|.|.:...|:|::|||:...:..::|.|:|:||.||.||: |..| :::...:::|:. ||:
Human   433 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLL 496

  Fly   499 FVILVSVLVLIKFLVQFIYRRF------ISKPKKEKTH 530
            .|:|....:..| ...:.||:.      :.|..|.|||
Human   497 AVVLTVAFITFK-CCAYGYRKCLGKKGRVKKAHKSKTH 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	133/509 (26%)
		UDPGT	37..526	CDD:278624	133/525 (25%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	136/532 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840