Protein Alignment Ugt37A3 and UGT1A4

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 131/527 - (24%)
• Similarity: 239/527 - (45%)
• Gaps: 80/527 - (15%)

  Fly    45 AAKVLAENGHNVTVVTVLKPVVNHK-------NITVIQVPLSKEEAQQMSDTIG---------AM 93
            |.:.|...||...|:|   |.||..       .:|...||.:::|..::  |:|         .:
Human    47 ALRELHARGHQAVVLT---PEVNMHIKEEKFFTLTAYAVPWTQKEFDRV--TLGYTQGFFETEHL 106

  Fly    94 SKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRGNKFDLVISGYFMNDFQLGFARK 158
            .|..:.:||:     .:.:...:.:....|:::.....:|| ...||:|::.
Human   107 LKRYSRSMAI-----MNNVSLALHRCCVELLHNEALIRHLN-ATSFDVVLTD------------- 152

  Fly   159 VNAPVIVLATMPPNHLLNPLI----GNPLEVSYAGIS--NPAE--------GSKAVTFQRRLSSY 209
               ||.:...:...:|..|.:    ..|.::.:.|..  ||:.        .|..:||.:|:.:.
Human   153 ---PVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNM 214

  Fly   210 MQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIE 274
            :..|......|.......:...|::..:..:   .:::...|:..|......:.| ||.:|:.:.
Human   215 LYPLALSYICHTFSAPYASLASELFQREVSV---VDLVSYASVWLFRGDFVMDYP-RPIMPNMVF 275

  Fly   275 IGGIQIKDKPDPLPQNIAEFLGNAT--DGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIW 337
            ||||...: ..||.|....:: ||:  .|.::.||||.|  ..:.......:.:.|.|:.:.|:|
Human   276 IGGINCAN-GKPLSQEFEAYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLW 336

  Fly   338 KWEDQENTPGKSA-NILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQP 401
            ::..  ..|...| |.:..|||||:|:|.||..:.||.|||..|:.||..:|.||:.:|:|.||.
Human   337 RYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQM 399

  Fly   402 RNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTE 466
            .||..|...|.|:||::|.:..:..:.|:..::::..|.|.:...|:|::|||:...:..::|.|
Human   400 DNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVE 464

  Fly   467 YVIRHHGAAHLQSPLVH-MSFIAANNIDIC-FLIFVILVSVLVLIKFLVQFIYRRF------ISK 523
            :|:||.||.||: |..| :::...:::|:. ||:.|:|....:..| ...:.||:.      :.|
Human   465 FVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKK 527

  Fly   524 PKKEKTH 530
            ..|.|||
Human   528 AHKSKTH 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	118/478 (25%)
		UDPGT	37..526	CDD:278624	127/521 (24%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	126/516 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840