Protein Alignment Ugt37A3 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 151/555 - (27%)
• Similarity: 253/555 - (45%)
• Gaps: 67/555 - (12%)

  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHK---- 69
            |.|.:.:....|.::...:| :.| :..||.....|..:.|...||.|.||   .|.|:.:
Human    10 LPLCVCLLLTCGFAEAGKLL-VVP-MDGSHWFTMRSVVEKLILRGHEVVVV---MPEVSWQLGRS 69

  Fly    70 -NITV--IQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMS--DQMDFMIRKNAETLMNDRVR 129
             |.||  .....:.|:..:..................|||..|  |..|... .|..:|..|:..
Human    70 LNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFF-SNCRSLFKDKKL 133

  Fly   130 DLYLNRGNKFDLVISGYFMNDFQ---LGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYA--- 188
            ..|| :.:.||.|    |::.|.   |..|:..:.|.:|.|.....|.|......|..:||.
Human   134 VEYL-KESSFDAV----FLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRI 193

  Fly   189 --GISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYK---EVYGNDPKMP--EYSEM 246
              |.|:      |:||:.|:.:::..|...:..|       .::|   |:.....:.|  || ::
Human   194 LLGFSD------AMTFKERVRNHIMHLEEHLLCH-------RFFKNALEIASEILQTPVTEY-DL 244

  Fly   247 LKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--DGAILLSLGS 309
            ..:||:....:....:.| :|.:|:.|.||||.. .:..|||.....:: ||:  .|.::.||||
Human   245 YSHTSIWLLRTDFVLDYP-KPVMPNMIFIGGINC-HQGKPLPMEFEAYI-NASGEHGIVVFSLGS 306

  Fly   310 NVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDDILAHPNIKLFI 373
            .|  ..:.......:.:.|.|:.:.|:|::..  ..|...| |.:..|||||:|:|.||..:.||
Human   307 MV--SEIPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFI 367

  Fly   374 NHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQ 438
            .|||..|:.||..:|.||:.:|:|.||..||..|...|.|:||::|.:..:..:.|:..::::..
Human   368 THAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKS 432

  Fly   439 YAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIC-FLIFVI 501
            |.|.:...|:|::|||:...:..::|.|:|:||.||.||: |..| :::...:::|:. ||:.|:
Human   433 YKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVV 496

  Fly   502 LVSVLVLIKFLVQFIYRRF------ISKPKKEKTH 530
            |....:..| ...:.||:.      :.|..|.|||
Human   497 LTVAFITFK-CCAYGYRKCLGKKGRVKKAHKSKTH 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	124/463 (27%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	143/528 (27%)