Protein Alignment Ugt37A3 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 142/566 - (25%)
• Similarity: 262/566 - (46%)
• Gaps: 80/566 - (14%)

  Fly    13 IAIGAVMGSSQGANILGLFPSLSP--------------SHLIIQMSAAKVLAENGHNVTVVTV-L 62
            :|.|..:...|.|..|.|..|:.|              ||.:....|.:.|...||.|.|:|: :
Human     1 MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVVLTLEV 65

  Fly    63 KPVVNHKN---ITVIQVPLSKEEAQQMSDTIG-AMSKNDNSNMALSLLR---MSDQMDFMIRKNA 120
            ...:..:|   :|...:..:::|..::  .:| ..|..:..::.:...|   :.:.|..:|.::.
Human    66 NMYIKEENFFTLTTYAISWTQDEFDRL--LLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSC 128

  Fly   121 ETLMNDR--VRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLA---TMPPNHLLNPLIG 180
            ..|:::.  :|.|:   ...||:|::    :.|.|..|        |||   ::|....|..:
Human   129 VELLHNEALIRHLH---ATSFDVVLT----DPFHLCAA--------VLAKYLSIPAVFFLRNI-- 176

  Fly   181 NPLEVSYAGIS--NPAE--------GSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYG 235
             |.::.:.|..  ||:.        .|..:||.:|:.:.:..|......|.......:...|::.
Human   177 -PCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ 240

  Fly   236 NDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT- 299
            .:..:   .:::.:.|:..|......:.| ||.:|:.:.||||...: ..||.|....:: ||:
Human   241 REVSV---VDLVSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCAN-GKPLSQEFEAYI-NASG 299

  Fly   300 -DGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDD 362
             .|.::.||||.|  ..:.......:.:.|.|:.:.|:|::..  ..|...| |.:..|||||:|
Human   300 EHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQND 360

  Fly   363 ILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQ 427
            :|.||..:.||.|||..|:.||..:|.||:.:|:|.||..||..|...|.|:||::|.:..:..:
Human   361 LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLE 425

  Fly   428 EAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANN 491
            .|:..::::..|.|.:...|:|::|||:...:..::|.|:|:||.||.||: |..| :::...::
Human   426 NALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHS 489

  Fly   492 IDIC-FLIFVILVSVLVLIKFLVQFIYRRF------ISKPKKEKTH 530
            :|:. ||:.|:|....:..| ...:.||:.      :.|..|.|||
Human   490 LDVIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKKAHKSKTH 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	129/517 (25%)
		UDPGT	37..526	CDD:278624	130/522 (25%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	129/527 (24%)
		egt	<262..508	CDD:223071	82/253 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840