Protein Alignment Ugt37A3 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 143/534 - (26%)
• Similarity: 250/534 - (46%)
• Gaps: 78/534 - (14%)

  Fly    37 SHLIIQMSAAKVLAENGHNVTVVTVLKPVVN-----HKNIT--VIQVPLSKEEAQQMSDTIGAMS 94
            ||.:......:||::.||.:.||.   |.||     .|..|  :..||..:||.:....:.|
Human    37 SHWLSMKDIVEVLSDRGHEIVVVV---PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFG--- 95

  Fly    95 KNDNSNMALSLLRMSDQMDF--------MIRKNAETLMNDRVRDLYLNRGNKFDLVIS------G 145
               |::.|......:.|.::        :...|.::|:.|| ..|...:.:|||.:.:      |
Human    96 ---NNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDR-DTLNFFKESKFDALFTDPALPCG 156

  Fly   146 YFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNP---AEGSKAVTFQRRLS 207
            ..:.:: ||.      |.:.|....|..|.:....:|..|||.    |   .:.|..:||.:|::
Human   157 VILAEY-LGL------PSVYLFRGFPCSLEHTFSRSPDPVSYI----PRCYTKFSDHMTFSQRVA 210

  Fly   208 SYMQS-----LGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRP 267
            :::.:     |.:.:||...|..:....::|        :...:.:..|:.........|.| ||
Human   211 NFLVNLLEPYLFYCLFSKYEELASAVLKRDV--------DIITLYQKVSVWLLRYDFVLEYP-RP 266

  Fly   268 NVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--DGAILLSLGSNVQGKHLNPDTVAKMFNVLSK 330
            .:|:.:.||||..|.:.| |.|....:: ||:  .|.::.||||.|  ..:.......:.:.|.|
Human   267 VMPNMVFIGGINCKKRKD-LSQEFEAYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGK 327

  Fly   331 LKERVIWKWEDQENTPGKSA-NILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSL 394
            :.:.|:|::..  ..|...| |.:..|||||:|:|.||..:.||.|||..|:.||..:|.||:.:
Human   328 IPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMM 390

  Fly   395 PVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARE 459
            |:|.||..||..|...|.|:||::|.:..:..:.|:..::::..|.|.:...|:|::|||:...:
Human   391 PLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLD 455

  Fly   460 SFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIC-FLIFVILVSVLVLIKFLVQFIYRRF-- 520
            ..::|.|:|:||.||.||: |..| :::...:::|:. ||:.|:|....:..| ...:.||:.
Human   456 LAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK-CCAYGYRKCLG 518

  Fly   521 ----ISKPKKEKTH 530
                :.|..|.|||
Human   519 KKGRVKKAHKSKTH 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	119/458 (26%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	138/523 (26%)