Protein Alignment Ugt37A3 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 155/570 - (27%)
• Similarity: 255/570 - (44%)
• Gaps: 97/570 - (17%)

  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHK---- 69
            |.|.:.:....|.::...:| :.| :..||.....|..:.|...||.|.||   .|.|:.:
Human    10 LPLYVCLLLTCGFAKAGKLL-VVP-MDGSHWFTMQSVVEKLILRGHEVVVV---MPEVSWQLGRS 69

  Fly    70 -NITVIQVPLSKEEAQQMSDTIGAMSKNDNSNM-------------ALSLLRMSDQMDF-MIRKN 119
             |.||           :...|...:...|...|             |.|||..|....| :...|
Human    70 LNCTV-----------KTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSN 123

  Fly   120 AETLMNDRVRDLYLNRGNKFDLVISGYFMNDFQ---LGFARKVNAPVIVLATMPPNHLLNPLIGN 181
            ..:|.|||....|| :.:.||.|    |::.|.   |..|:..:.|.:|.|.....|.|......
Human   124 CRSLFNDRKLVEYL-KESCFDAV----FLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQC 183

  Fly   182 PLEVSYA-----GISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMP 241
            |..:||.     |.|:      |:||:.|:.:::..|...:|...       ::|.|      :.
Human   184 PAPLSYVPRLLLGFSD------AMTFKERVWNHIMHLEEHLFCPY-------FFKNV------LE 229

  Fly   242 EYSEMLK----------NTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLG 296
            ..||:|:          :||:....:....|.| :|.:|:.|.||||.. .:..|:|.....::
Human   230 IASEILQTPVTAYDLYSHTSIWLLRTDFVLEYP-KPVMPNMIFIGGINC-HQGKPVPMEFEAYI- 291

  Fly   297 NAT--DGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWL 358
            ||:  .|.::.||||.|  ..:.......:.:.|.|:.:.|:|::..  ..|...| |.:..|||
Human   292 NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWL 352

  Fly   359 PQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEE 423
            ||:|:|.||..:.||.|||..|:.||..:|.||:.:|:|.||..||..|...|.|:||::|.:..
Human   353 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS 417

  Fly   424 KPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFI 487
            :..:.|:..::::..|.|.:...|:|::|||:...:..::|.|:|:||.||.||: |..| :::.
Human   418 EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWY 481

  Fly   488 AANNIDIC-FLIFVILVSVLVLIKFLVQFIYRRF------ISKPKKEKTH 530
            ..:::|:. ||:.|:|....:..| ...:.||:.      :.|..|.|||
Human   482 QYHSLDVIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKKAHKSKTH 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	142/521 (27%)
		UDPGT	37..526	CDD:278624	146/536 (27%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	147/543 (27%)
		egt	<264..504	CDD:223071	80/246 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840