Protein Alignment Ugt37A3 and UGT1A8

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 148/552 - (26%)
• Similarity: 256/552 - (46%)
• Gaps: 65/552 - (11%)

  Fly    11 LAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHK-----N 70
            |.:::....|.::...:| :.| :..||.....|..:.|...||.|.||   .|.|:.:     |
Human    12 LCVSLLLTCGFAEAGKLL-VVP-MDGSHWFTMQSVVEKLILRGHEVVVV---MPEVSWQLGKSLN 71

  Fly    71 ITVIQVPLS---KEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLY 132
            .||.....|   ::..::..|...|..|....::....|..|:....:...:..:|.|||....|
Human    72 CTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEY 136

  Fly   133 LNRGNKFDLVISGYFMNDFQ---LGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYA-----G 189
            | :.:.||.|    |::.|.   |..|:..:.|.:|.|.....|.|......|..:||.     |
Human   137 L-KESSFDAV----FLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLG 196

  Fly   190 ISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYK----EVYGNDPKMPEYS-EMLKN 249
            .|:      |:||:.|:.:::.        ||.|.....::.    |:.....:.|..: ::..:
Human   197 FSD------AMTFKERVRNHIM--------HLEEHLFCQYFSKNALEIASEILQTPVTAYDLYSH 247

  Fly   250 TSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--DGAILLSLGSNVQ 312
            ||:....:....:.| :|.:|:.|.||||.. .:..|||.....:: ||:  .|.::.||||.|
Human   248 TSIWLLRTDFVLDYP-KPVMPNMIFIGGINC-HQGKPLPMEFEAYI-NASGEHGIVVFSLGSMV- 308

  Fly   313 GKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDDILAHPNIKLFINHA 376
             ..:.......:.:.|.|:.:.|:|::..  ..|...| |.:..|||||:|:|.||..:.||.||
Human   309 -SEIPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHA 370

  Fly   377 GKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAE 441
            |..|:.||..:|.||:.:|:|.||..||..|...|.|:||::|.:..:..:.|:..::::..|.|
Human   371 GSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKE 435

  Fly   442 RVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIC-FLIFVILVS 504
            .:...|:|::|||:...:..::|.|:|:||.||.||: |..| :::...:::|:. ||:.|:|..
Human   436 NIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTV 499

  Fly   505 VLVLIKFLVQFIYRRF------ISKPKKEKTH 530
            ..:..| ...:.||:.      :.|..|.|||
Human   500 AFITFK-CCAYGYRKCLGKKGRVKKAHKSKTH 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	122/462 (26%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	141/527 (27%)