Protein Alignment Ugt37A3 and UGT2B28

DIOPT Version :9

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 142/569 - (24%)
• Similarity: 241/569 - (42%)
• Gaps: 98/569 - (17%)

  Fly     9 LLLAIAIGAVMGSSQGANIL---GLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKN 70
            :||.|.:|....|.....:|   |.:     ||.:...:..|.|.:.||.|||:.....::...|
Human     8 VLLLIHLGCYFSSGSCGKVLVWTGEY-----SHWMNMKTILKELVQRGHEVTVLASSASILFDPN 67

  Fly    71 ------ITVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSD-QMD-FMIRKNAETLMNDR 127
                  :.|....|:|.|.:.:              :...:.|.|| |.| |.:..:.|..:...
Human    68 DAFTLKLEVYPTSLTKTEFENI--------------IMQQVKRWSDIQKDSFWLYFSQEQEILWE 118

  Fly   128 VRDLYLN---------------RGNKFDLVISGYFMNDFQLG--FARKVNAPVIVLATMPPNHLL 175
            ..|::.|               :.::||::.:..|   |..|  .|..:|.|.:......|
Human   119 FHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAF---FPCGELLAALLNIPFVYSLCFTP---- 176

  Fly   176 NPLIGNPLEVSYAGISNP--------AEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNW--- 229
                |..:|....|:..|        ::.|..:||..|:.:.:..|.|..:..:.:.  :.|
Human   177 ----GYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDM--KKWDQF 235

  Fly   230 YKEVYGND----PKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQN 290
            |.||.|..    ..|.:....|...|..|...|     |..||:..   :||:..| ...|||:.
Human   236 YSEVLGRPTTLFETMGKADIWLMRNSWSFQFPH-----PFLPNIDF---VGGLHCK-PAKPLPKE 291

  Fly   291 IAEFL-GNATDGAILLSLG---SNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTP-GKSA 350
            :.||: .:..:|.::.|||   ||:..:..|....|     |:|:.::|:|:::.  |.| ....
Human   292 MEEFVQSSGENGVVVFSLGSVISNMTAERANVIATA-----LAKIPQKVLWRFDG--NKPDALGL 349

  Fly   351 NILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLT 415
            |....||:||:|:|..|..:.||.|.|..||.|:.|||.||:.:|:|.|||.|...|...|..:.
Human   350 NTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVR 414

  Fly   416 LSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSP 480
            |...|:.......|:..::::|.|.|.|...|.:..|:|:......::|.|:|:.|.||.||:..
Human   415 LDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVA 479

  Fly   481 LVHMSFIAANNIDIC-FLIFVILVSVLVLIKFLVQFIYRRFISKPKKEK 528
            ...:::...:::|:. ||:..:...:.|:.||.: |.:.:|..|.||.|
Human   480 ARDLTWFQYHSLDVIGFLLACVATVIFVVTKFCL-FCFWKFARKGKKGK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	130/528 (25%)
		UDPGT	37..526	CDD:278624	132/534 (25%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	134/549 (24%)
		egt	<269..506	CDD:223071	74/247 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840