DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	278/517 - (53%)
Similarity:	374/517 - (72%)	Gaps:	6/517 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITVIQ 75
            ||:.|..::..:.||||||||.|||||||:||||.|::|||.||||||||:|||...||:|..|.
  Fly     8 LALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHIL 72

  Fly    76 VPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRGNKFD 140
            ||:.::..|..:..:|.|:|.||||..:|:.|...|:.....|..:.:....|:|||.:..||||
  Fly    73 VPMEEDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVMKQPLVKDLYEHPDNKFD 137

  Fly   141 LVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYA-GISNPAEGSKAVTFQR 204
            ||:.|||||.:||..|.|:..|::|..:.||: .|..|:|||.||||. |:|...:|.|.:.|..
  Fly   138 LVMVGYFMNCYQLALAHKLKVPLVVALSNPPS-FLGYLLGNPWEVSYVPGMSVSIKGGKPLGFGH 201

  Fly   205 RLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNV 269
            |:.:.:.|:...:|..:.|.||...|:|:||:||.:|.|.::.||.||:||:||..|||||||||
  Fly   202 RVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNV 266

  Fly   270 PSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKER 334
            |:.|||||||:|::|:.||||:.:||..|.:||||||||||::..||...||.|||||||||:::
  Fly   267 PAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQK 331

  Fly   335 VIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFAD 399
            |||||:|.:|.||:|.|||||||:||.|:||||||.|||.||||||:||:||||||||:||||.|
  Fly   332 VIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPVFGD 396

  Fly   400 QPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYW 464
            ||.||:.||..|||:..|:|||||..|.:.|.|:|.||:||..||||||||||||::.||:.:||
  Fly   397 QPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETLIYW 461

  Fly   465 TEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRFISKPKK 526
            .|||||:|||.|:|||:||||:|||||:|    ::.:::..:|.:.|:.:.::...:.|.:|
  Fly   462 VEYVIRYHGAPHIQSPVVHMSYIAANNLD----VYAVILGTIVALCFITKLLFGLVVGKLRK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	270/479 (56%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	262/489 (54%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	276/513 (54%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	264/470 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445654
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2282
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm50532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.900