DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	268/529 - (50%)
Similarity:	356/529 - (67%)	Gaps:	21/529 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNIT 72
            ||||.    .|:.|:|||||||||.|.|||||||.||.||.|.:.|||||||::|||.|.||:|.
  Fly     8 FLLLL----GVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIH 68

  Fly    73 VIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRGN 137
            :|.||:.:|:.:.|.|.:..|:...|| :..::.|:...||.||...||.|.:.|.:.:|   ..
  Fly    69 LIVVPMKEEQERIMEDQMTEMAGQKNS-LVSTMYRLLTSMDVMINAQAELLSDPRFQRIY---ET 129

  Fly   138 KFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNPAEGSKA--- 199
            ||||:|.|||:||||||.|.|:..|||:.....|...::...|||.|:||.    |..|:.|
  Fly   130 KFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYV----PLMGTVATQP 190

  Fly   200 VTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGP 264
            :.|.:|..:.::||.|.....:.:.:....|.:|: .:..||...|:.||.|:.|..||..||||
  Fly   191 MGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVF-PEQDMPTLKELRKNISMAFVGSHLISEGP 254

  Fly   265 IRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLS 329
            |||.||:.|||||||:||||||||::|.:|:.||..||:.|||||||:...:.|:.|..:|.|||
  Fly   255 IRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLS 319

  Fly   330 KLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSL 394
            :|||.|||||||.|||||.|:||||..||||||||||||.||||.|||||||||:||||.||::|
  Fly   320 ELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVAL 384

  Fly   395 PVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARE 459
            |:|.|||.||..|.|||:||.|.||::.|...::|:.|:|.|.:|.:.:..||||||||||||::
  Fly   385 PIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQ 449

  Fly   460 SFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRF---- 520
            |.::||||::||.||.:||||.|||:||..||:||..||..|||..::|.:.:.:.::.:|
  Fly   450 SVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVWNKFGGKA 514

  Fly   521 -ISKPKKEK 528
             ||:.||::
  Fly   515 KISQTKKKQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	253/484 (52%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	248/496 (50%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	244/471 (52%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	246/490 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445661
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	347	1.000	Inparanoid score	I4534
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm50532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.900