DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt35C1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001097744.1	Gene:	Ugt35C1 / 53507	FlyBaseID:	FBgn0040256	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	184/535 - (34%)
Similarity:	284/535 - (53%)	Gaps:	40/535 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLAIAI-----GAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNH 68
            ||..|||     .|....|:.|.||...|....|..|...|..|.||..||.|||:...|   |.
  Fly     3 LLTVIAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFK---NK 64

  Fly    69 K--NITVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDL 131
            :  |:..|:...:.|.|.:|...:         |:.| |.:..:.||:::.|..:..|.|.....
  Fly    65 ETPNMRFIEALKAHEFADEMMSLL---------NVPL-LWQQLNAMDYILNKFIDVTMEDEGVQR 119

  Fly   132 YLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNP--- 193
            .||.|..||||::.....:....||:..||.::..::...:..::...||...:||    ||
  Fly   120 LLNSGETFDLVLAEMLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNISPISY----NPLVT 180

  Fly   194 AEGSKAVTFQRRLSSYMQSLGFGV---FSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFF 255
            :..:..:||..||.::.:.:...:   |.||...  ||.||:.:.|..|..|  |::.:.||:..
  Fly   181 SPRTDRMTFLERLENHYEVIVEDIHRHFVHLPHM--RNVYKKYFPNAKKTLE--EVMDSFSLILL 241

  Fly   256 SSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDT 320
            ..|.:...| ||.:|:.||:||:.|..||.|||::|.:|:..:..|.|..|:||||:.|.|..:|
  Fly   242 GQHFSLSYP-RPYLPNMIEVGGMHISHKPKPLPEDIKQFIEGSPHGVIYFSMGSNVKSKDLPQET 305

  Fly   321 VAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQ 385
            ...:....:|||:||:||:|| ::.|||.||:|..||.||.|||||||:||||:|.|....|||.
  Fly   306 RDTLLKTFAKLKQRVLWKFED-DDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESV 369

  Fly   386 YHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLY 450
            |.|||:|.||.|.||..|.....:.||||.|.|..|:::..::||..:|::|.||:...:.|..|
  Fly   370 YFGKPILGLPCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERY 434

  Fly   451 RDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQF 515
            ||:|.:|.:..::||||||||:||.||::....::||..|::|    ...::::|.:|:..|:..
  Fly   435 RDQPQSAVDRAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLD----TLAVILAVPLLLALLIVT 495

  Fly   516 IYRRFISKPKKEKTH 530
            :..:.:...|::..|
  Fly   496 LSCKLLGGKKQKCLH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	177/493 (36%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	171/496 (34%)
Ugt35C1	NP_001097744.1	egt	1..470	CDD:223071	175/489 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	8.070