DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	173/544 - (31%)
Similarity:	274/544 - (50%)	Gaps:	69/544 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVL---KPVVNHKNITVIQVPLSKE 81
            |...||.||.|||..|.||....:...|.||..||.:|.|:..   :||.|..:|.|.:|..|.:
  Fly    16 GFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKNIYDIYVPEVLNSFD 80

  Fly    82 E-AQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRGN-KFDLVIS 144
            | .:||:.........|.:|            :|:.....:...||.||...|..|. :|||:|.
  Fly    81 ELLKQMTTPKNTWEFFDATN------------EFVYNITKDVFNNDGVRREILRPGKAQFDLIIV 133

  Fly   145 GYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNPAEGSKAVTFQRRLSSY 209
            ..:..|.....|....||:|.||....:..::.::|||..:||  :.:|             |||
  Fly   134 DIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSY--LQSP-------------SSY 183

  Fly   210 MQSLGF--GVFSHLSERR----NRNW---------YKEVYGNDPKMPE---YSEMLKNTSLVFFS 256
            :.:|..  |..:|:.|..    |.:|         ||:.:   ||:.|   .||:.::.:||..:
  Fly   184 LYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYF---PKIAETKPLSEISQDIALVLVN 245

  Fly   257 SHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKHLNPDT 320
            .| .:.||.||.||:.||:||:.|.::|..|.|::.:|: |:...|.|..|||:||:.|::..|.
  Fly   246 QH-FTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDR 309

  Fly   321 VAKMFNVLSKLKERVIWKWEDQE--NTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITE 383
            ...:......|.:||:||:||:|  :.|   :|:|..|||||.|:||||.:||||.|.|.....|
  Fly   310 KRILIEAFGSLPQRVLWKFEDEELQDIP---SNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIE 371

  Fly   384 SQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFST 448
            |.::|||||.||.|.||..|.:.:.|.||.|:|:...:.....:..||::|:..::....:....
  Fly   372 SIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGA 436

  Fly   449 LYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNID----ICFLIFVILVSVLVLI 509
            .|||:||...|:.::||.||:||.||.|::.....:||...:::|    :..:|.::::::|::|
  Fly   437 RYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLII 501

  Fly   510 KFLV-----QFIYRRFISKPKKEK 528
            .|.|     ....|..:.|.:|:|
  Fly   502 VFSVCKISKNISTRLVVKKQRKQK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	163/495 (33%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	162/523 (31%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	158/478 (33%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	155/484 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445789
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	9.000