DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt303A1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	141/545 - (25%)
Similarity:	241/545 - (44%)	Gaps:	92/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLAIAIGAVMGSSQGA-NILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNIT 72
            ||..:..|.:......| |||.:|.....|..::.....:.|.:.||.:|:::.:..:.:.:.:.
  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVH 75

  Fly    73 VIQVP-----------------LSK-EEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKN 119
            .|:||                 |:| .|||.:|:.....||                  |:
  Fly    76 HIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSK------------------FV---- 118

  Fly   120 AETLMNDRVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLE 184
               |.:..|::|..|...|:.|:|.....||...||::..|||::.:|....:..::.|:||
  Fly   119 ---LEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGN--- 177

  Fly   185 VSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPE------- 242
             |...:..|                |.:||:....:|.|:    |:..:|..:.::.|
  Fly   178 -SAPSVYEP----------------MSALGYTSGLNLIEK----WHNLIYITEERLVERFIYLPR 221

  Fly   243 ---------------YSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIA 292
                           ..::.:..|||..:.| .:.|.:|.|||:.:|:.|:.:.:||.||...:.
  Fly   222 QIDLYKQHFPGATTSIHDLRRRFSLVLINQH-FTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELK 285

  Fly   293 EFLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKW 357
            :.|..|..|.|..|:|..:....|.|...|.|.:..::||::|||| .|......:|.|:....|
  Fly   286 KILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWK-TDYPEMVNQSRNVFARTW 349

  Fly   358 LPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLE 422
            .||..||.|||:||||.|||...:.||.::..|:|.:|:|.||.:|...|.|.|....|....|.
  Fly   350 FPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLF 414

  Fly   423 EKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFI 487
            ......||.:::.|..|....:..|..:.|:||:|.::.::||||::||.||.|::.....||.:
  Fly   415 RDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLM 479

  Fly   488 AANNIDICFLIFVILVSVLVLIKFL 512
            ...|:|:..::|..:....:::.||
  Fly   480 QYYNVDVVSVLFGRIGLSAIIVIFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	136/521 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	133/516 (26%)
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	128/489 (26%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	133/517 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445784
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	9.000