DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt304A1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	149/519 - (28%)
Similarity:	255/519 - (49%)	Gaps:	49/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHK--NITVIQVPLSKEEAQQ 85
            :.:.||.:.|..|.|..::.....:.|.:.||.:||:...|..: ||  ::|.|::..:.....:
  Fly    23 RSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCM-HKIEDVTFIRIWYNNNVFLE 86

  Fly    86 MSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRGNKFDLVI--SGYFM 148
            ..:::|..|.|:...      .:|.....|.......|.|..||.|..:| ..||.|:  :||
  Fly    87 FEESVGIASANNKWE------EISSMSSLMANATLNVLNNVEVRALMKSR-ITFDAVVLEAGY-- 142

  Fly   149 NDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNPAEGSKAVTFQRRLSSYMQSL 213
            :|...|.|...:|.:|.:.|...:..:|.|:|    .|.:.::.|....:|        .|::::
  Fly   143 SDVLYGMAAHFSAQLIGICTCVADWNINNLVG----FSTSTLTEPIMPFRA--------KYVKNV 195

  Fly   214 GFGVFSHL--SER----------RNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIR 266
            ...:::.|  :|.          :.|..:...:|:..|  .:.|:.::.:|:..:.| .|....|
  Fly   196 WDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEK--SFHEIRQDFALMLLNQH-FSLFRAR 257

  Fly   267 PNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKL 331
            ||||..:|:.|:.|..:...||.::..|:..|..|.||.|||.....|.|...|...:......:
  Fly   258 PNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEAEHGVILFSLGLEQDSKDLPRKTQEILVETFKSV 322

  Fly   332 KERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPV 396
            .:|||||: |.|:|.....:|.:||.|||..||||||:||||:|.|...:.|:.|:.||:|.||.
  Fly   323 PQRVIWKF-DGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPS 386

  Fly   397 FADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESF 461
            |.||.||...|.:.|..|.|::.:|..|..::||..:::.|:|.|...:.|..:||:|:...::.
  Fly   387 FFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAA 451

  Fly   462 LYWTEYVIRHHGAAHL---QSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRFIS 522
            :|||||:||:.||.|:   ||.|....:.:.:|    |::....:|::|.:.|||....||:::
  Fly   452 IYWTEYIIRYKGADHMKISQSQLKLFDYYSLDN----FIMVGSRLSLVVALVFLVLSKSRRWLN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	140/485 (29%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	145/505 (29%)
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	140/482 (29%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	121/428 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445786
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	8.000