DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	144/539 - (26%)
Similarity:	248/539 - (46%)	Gaps:	62/539 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNIT 72
            :|.|::.:......:|.|||||:||....|...:.....:.||..|||||::|.:....:.:.:.
  Fly     7 WLTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVR 71

  Fly    73 VIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQ-MDFMIRKNAETLM---------NDR 127
            .|:|....|..::|.:                    ||| :||||.|..|:.:         ||.
  Fly    72 HIRVAQLNERIKEMLE--------------------SDQVLDFMINKWTESALTAKALFNASNDI 116

  Fly   128 VRD-----LYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSY 187
            :.|     :..::...|||:|......|...|.....||.::.|:::..|.....|.|||....|
  Fly   117 LSDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSIY 181

  Fly   188 AGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNW----------YKEVYGNDPKMPE 242
            ..|| |...|...:...|:.:::         |:.|.:..|:          :::.:|...:  :
  Fly   182 EPIS-PVGFSLETSLFSRVYNWI---------HIMEEKLVNYLILRPAQLHLFQKFFGYSAQ--K 234

  Fly   243 YSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSL 307
            .:|:....||:..:|| .|.|.:|.|.|:.||:||:.:.:.|:|..:.:.:||..|..|.|..|:
  Fly   235 MNELRSRFSLMLINSH-YSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSM 298

  Fly   308 GSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLF 372
            |:::..|.|..:....:....:.|.|.:||| .:....|.||.|:...:..||..||.|||::||
  Fly   299 GNDILIKFLPENIQELLLQTFATLNESIIWK-SELLYMPDKSDNVYVVEQAPQRHILNHPNVRLF 362

  Fly   373 INHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNP 437
            |.:.|...:.|:...|.|||.||:|.||..|...:..||....:.:.:|.:....|.|..:|:|.
  Fly   363 ITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANN 427

  Fly   438 QYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNID--ICF-LIF 499
            .|..:.|..|..::||||:..::.::||||.:|:.....::..|..:..|....||  :.| |.|
  Fly   428 SYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRF 492

  Fly   500 VILVSVLVLIKFLVQFIYR 518
            .::.:.|:.:.:.:...||
  Fly   493 GLVAASLIFLVYTLFLKYR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	136/506 (27%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	134/510 (26%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	132/474 (28%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	131/503 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445790
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950