DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	143/545 - (26%)
Similarity:	251/545 - (46%)	Gaps:	64/545 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLAIAIGAVM-GSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITV 73
            :|.:.:|.:: |...|||:|.:|||:..||.:......:.|.|:..|.: ||::.|....:.:..
  Fly     3 ILQVFLGTLLCGIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHS-VTLISPHAAQEGVDA 66

  Fly    74 IQVPLSKE-----------------EAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAE 121
             ::|..:|                 ||::|              .|.|::....::.:....|.:
  Fly    67 -EIPKIRELRIEGLRENWLDMGMSFEAEEM--------------RAQSVMERFTRLIYAGTTNVD 116

  Fly   122 TLMND-RVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEV 185
            .|::| :||.| |..|.||||:|...|::|..||.|.....|.:.::....|..||.:.|||...
  Fly   117 ILLSDPQVRKL-LTSGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSS 180

  Fly   186 SYAGISNPAE----GSKAVTFQRRLSSYM---QSLGFGVFSHLSERRNRNWYKEVYGND-----P 238
            |.    :|:.    ..:..|.||.|:|.|   :.|.:..|..:|:       :.||.|.     .
  Fly   181 SL----DPSNFLPFTERMNTRQRILNSLMSTFERLTYNFFHLISQ-------QSVYTNHFELLVK 234

  Fly   239 KMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKD-KPDPLPQNIAEFLGNATDGA 302
            ::|.|.::.||.||...:||.....| |..:|:.:|:||:.:.. ..|.||:::..|:.:|..|.
  Fly   235 ELPLYRDLTKNLSLALINSHPGLHYP-RAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESAPSGV 298

  Fly   303 ILLSLGSNVQGKHLNPDTVAKMFNVLSKLKE-RVIWKWEDQENTPGK--SANILYSKWLPQDDIL 364
            |..|||::|:...|..:.:|.:.:|...||| ..:.|||.:|.|..:  ..|::.:.|.||..||
  Fly   299 IYFSLGADVETAQLPQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAIL 363

  Fly   365 AHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEA 429
            .||.:|:||:..|:..:.||....||:|::|:.|:|...|..:.:.|..:|:...:|........
  Fly   364 HHPQVKMFISSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHG 428

  Fly   430 ILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDI 494
            |.::..|..|.|::.........|..|.....:...:.::...||..|:|....::|..|..:|:
  Fly   429 IRQLTLNTSYVEKLGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDV 493

  Fly   495 CFLIFVILVSVLVLIKFLVQFIYRR 519
            ..:|.|....:|.:....:.||.|:
  Fly   494 LLIIAVGFFGILTIPFLAICFILRK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	135/514 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	133/517 (26%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	134/505 (27%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	116/437 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445793
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.950