Protein Alignment Ugt37A3 and Ugt1a1

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_964007.2
• Gene: Ugt1a1 / 394436
• MGIID: 98898
• Length: 535
• Species: Mus musculus
• Alignment Length: 563
• Identity: 149/563 - (26%)
• Similarity: 249/563 - (44%)
• Gaps: 80/563 - (14%)

  Fly     9 LLLAIAIGAVMG-SSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVV------------- 59
            |||...:..|.| |:..|..|.:|| :..||.:..:...:.|.:.||.|.|:
Mouse    12 LLLPYLLLCVFGPSASHAGRLLVFP-MDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSF 75

  Fly    60 -TVLK-PVVNHK-NITVIQVPLSKEEAQQMSDTIGAMS-----KNDNSNMALSLLRMSDQMDFMI 116
             |:.| ||...| |:|...|.|.:....|.|..:..:.     |.|:|.:......:....:||.
Mouse    76 YTLRKFPVPFQKENVTATLVELGRTAFNQDSFLLRVVKIYMKVKRDSSMLLAGCSHLLHNAEFMA 140

  Fly   117 RKNAETLMNDRVRDLYLNRGN---KFDLVISGYFMNDFQLGF-ARKVNAPVIVLATMPPNHLLNP 177
            ... |:..:..:.|.:|..|:   ::..|.:.||:|...... :.....||             |
Mouse   141 SLE-ESHFDALLTDPFLPCGSIVAQYLTVPTVYFLNKLPCSLDSEATQCPV-------------P 191

  Fly   178 LIGNPLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFG-----VFSHLSERRNRNWYKEVYGND 237
            |...|..:|:        .|..:.|.:|:.:.:.::...     |:|...........|||...|
Mouse   192 LSYVPKSLSF--------NSDRMNFLQRVKNVLLAVSENFMCRVVYSPYGSLATEILQKEVTVQD 248

  Fly   238 PKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--D 300
                    :|...|:....|....:.| ||.:|:.:.||||....| .||.|....:: ||:  .
Mouse   249 --------LLSPASIWLMRSDFVKDYP-RPIMPNMVFIGGINCLQK-KPLSQEFEAYV-NASGEH 302

  Fly   301 GAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYSKWLPQDDIL 364
            |.::.||||.|  ..:......::...|.::.:.|:|::..  ..|...| |.:..|||||:|:|
Mouse   303 GIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLL 363

  Fly   365 AHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEA 429
            .||..:.||.|:|..||.|...:|.||:.:|:|.||..||..|...|.|:||::|.:.....:.|
Mouse   364 GHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENA 428

  Fly   430 ILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-MSFIAANNID 493
            :..:::|..|.|.:...|:|::|||:...:..::|.|||:||.||.||: |..| :::...:::|
Mouse   429 LKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLD 492

  Fly   494 IC-FLIFVILVSVLVLIKFLVQFIYRRF-----ISKPKKEKTH 530
            :. ||:.::|..|.::.|.......:.|     :.|..|.|||
Mouse   493 VIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	119/471 (25%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	137/534 (26%)