DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	173/556 - (31%)
Similarity:	273/556 - (49%)	Gaps:	70/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLAIAIGAV-MGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVL-----KPVV 66
            |||..:|:..: :|:  |:.||..|.....||.::..:..:.|.:.||.||.:|..     |...
  Fly    10 FLLSLVALQQLELGT--GSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGS 72

  Fly    67 NHKNITVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQM-----DFMIRK-NAETLMN 125
            |:|.|.:.|... ..|.::|::....:...|....|  .|||.:.|     ||.:.: ..:.::|
  Fly    73 NYKEIVIPQYDF-WPEIKEMTNKNTVLEMTDLPTFA--FLRMVNVMGIHTTDFALEQPEIQAVIN 134

  Fly   126 DRVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGI 190
            ::      |:..|:||:::..|.|:..|........|.|.::|....:.|:.|.|.....||...
  Fly   135 EK------NKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPH 193

  Fly   191 SNPAEGSKAVTFQR-------------RLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPE 242
            :......:...::|             |..||.......:..|.|:..:|            :|.
  Fly   194 AYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDR------------VPT 246

  Fly   243 YSEMLKNTSLVFFSSH--AASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILL 305
            ..|:.:|.|.:..:|:  .||..|:..|:   |.:||:.|: .|..||:::.:||..||.|||..
  Fly   247 IKELERNISAILLNSYMPLASSRPMAYNM---IPVGGLHIQ-PPKALPEHLQKFLDGATHGAIYF 307

  Fly   306 SLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIK 370
            ||||.|:...|.|:.:.....|...||:||:||:|| |:.|...||:....||||.|||||||:|
  Fly   308 SLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFED-ESLPNLPANVKVQSWLPQGDILAHPNVK 371

  Fly   371 LFINHAGKGGITESQYHGKPMLSLPVFADQPRNAN--AMVKSGFGLTLSLLTLEEKPFQEAILEI 433
            :||.|.|..|..|:.|:|.|:|.:||:.||.:|.|  ...:...||....:|:||  .:..::|:
  Fly   372 VFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEE--LRGLLMEL 434

  Fly   434 LSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFL- 497
            :.||:|...:|..|.::||||:.|.::.:||..|||.|.||.||.:..||:.:.....:||..|
  Fly   435 IENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLG 499

  Fly   498 IFVILVSVLVLIKFLVQFIYRRFISKPK----KEKT 529
            :.|||:.::|||     .|.|| .||||    |:||
  Fly   500 LAVILLPIVVLI-----LICRR-SSKPKSTPTKKKT 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	154/510 (30%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	161/521 (31%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	163/537 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	155/509 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454754
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.990