DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-35

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001023694.1	Gene:	ugt-35 / 3565443	WormBaseID:	WBGene00044286	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	143/576 - (24%)
Similarity:	245/576 - (42%)	Gaps:	109/576 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHK----- 69
            :|...|..:..:|:..|.|...|..:.||.......|..|:|.|||   ||.|.|::..|
Worm     7 ILFFLISILFQNSKSVNFLVYCPLFAHSHHTFLAKIADTLSEEGHN---VTFLAPIIVQKYENFK 68

  Fly    70 ------NITVIQVPLSKEEAQQMSDTIGA------MSKNDNSNMALSLLRMSDQMDFMIRKN--A 120
                  :|..||   ..||.:::.:.:|:      .::..:....:..:::..:|...|.:|  |
Worm    69 YLKHTTDIIYIQ---PDEELKKLGEIMGSAGFSKYWTEEPSVFSMIPSIKLFQKMFHKIYENLRA 130

  Fly   121 ETLMNDRVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNH------LLNPLI 179
            :..:.|.::|      .|||.:|  |.:    |.|........:.:.|:.|..      :|:..|
Worm   131 DLSILDSLKD------RKFDAMI--YEV----LAFNAIAIQQYLGIKTLYPTFSVTHGMVLSKSI 183

  Fly   180 GNPLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRN----WYKEVYGNDPKM 240
            |.|        ::||      |....||.|.:.:.|       :.|..|    :..:|:...|||
Worm   184 GEP--------ASPA------TLSSALSPYGEKMNF-------QERLMNTVCAFIYQVFMKPPKM 227

  Fly   241 PEYS---------EMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKD---KPDPLPQNIAE 293
            ..||         |.....|.||.:|:...:.| ||.:...:.||||.:..   :.:.|......
Worm   228 ISYSHPYYEIDLKEAESKASFVFLNSNPYLDFP-RPMLTKTVLIGGISVNTSQIREERLSDEYHN 291

  Fly   294 FLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKER-----VIWKWE-DQENTPGKSANI 352
            .| |.....:|:|.||.:    |:.|...:..:::.|:.|.     .|||:| |:.:......|:
Worm   292 IL-NIRVKTVLISFGSIM----LSTDMPDRYKSIIVKVIEEFPNVTFIWKYESDELDFANNLKNL 351

  Fly   353 LYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLS 417
            .:.||:||..:||...:..||.|||.|.|.|..|.|||.:.:|:||||.|||..:|:....::|.
Worm   352 HFFKWIPQTALLADSRLSAFITHAGLGSINELSYMGKPAILVPIFADQLRNAKMLVRHNGSISLE 416

  Fly   418 LLTLEE-KPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRH--HGAAHLQS 479
            ...|.. :..:.::.:||.:..:.|..:..:....::|::.|       |.:|:|  .||...:.
Worm   417 KQDLGNFEKLRVSLAKILKDNSFQENAEILARQLNNQPISPR-------ELLIKHATFGAEFGEL 474

  Fly   480 PLV-----HMSFIAANNIDICFLIFVILVSVLVLIKF-LVQFIYRRFISKPKKEKT 529
            |.:     .|||.:.|.||| ||...:.:::||...| .::.:....:.|...||:
Worm   475 PSLDPYSRQMSFFSLNMIDI-FLFLGVFLAILVYFLFTFLRLLLNLLLKKKAVEKS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	131/534 (25%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	135/544 (25%)
ugt-35	NP_001023694.1	Glycosyltransferase_GTB_type	2..464	CDD:299143	124/508 (24%)
ugt-35	NP_001023694.1	UDPGT	34..506	CDD:278624	131/524 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910