DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-39

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504816.2	Gene:	ugt-39 / 3564933	WormBaseID:	WBGene00017329	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	536	Identity:	129/536 - (24%)
Similarity:	226/536 - (42%)	Gaps:	52/536 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVV--NHKNIT-------VIQ 75
            |:....|.|...|..:.||.....:.|..|.:.|||||..|   |.:  .::|::       |:.
Worm    12 GNVSSFNFLVFCPLFAHSHSKFFATIADSLTDAGHNVTFFT---PTIVEKYRNVSYTKSTKDVVH 73

  Fly    76 VPLS---KEEAQQMS--DTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNR 135
            :..|   ||..:|||  |.:...:::..:...:.::|:..:|    .....|:|.|.|..|...:
Worm    74 MKPSKKLKEYGEQMSTGDFVRYWTEDSTATEIIPVVRIFQKM----YNEQGTVMKDNVGILNELK 134

  Fly   136 GNKFDLVI------SGYFMNDFQLGFARKVNAPVIV-LATMPPNHLLNPLIGNPLEVSYAGISNP 193
            ..|||::|      |.|.:.|:       :..|..: ..::..:..|...||.|:..|.......
Worm   135 KRKFDVIIFEAYIYSAYPLMDY-------LEIPTFIPSVSVAHDTSLAIEIGEPVMPSVVSDCLS 192

  Fly   194 AEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSH 258
            ..|.|....:|..:::|......:..:.:.|..:..|..:        :...::...|.||.:|:
Worm   193 PFGDKLSITERAFNAFMVPYFDFMIGYPTHRSFKPPYNPI--------DIRSIVPEASFVFLNSN 249

  Fly   259 AASEGPIRPNVPSAIEIGGIQIKD---KPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDT 320
            ...:.| ||.:...|:||||.:..   :...|.:..:|.| ...:..:|:|.||.:..|.:....
Worm   250 PFVDFP-RPTLTKTIQIGGISVDSNELRSQKLDETWSEIL-KLREKTMLVSFGSMLYSKDMPFKN 312

  Fly   321 VAKMFNVLSKLKE-RVIWKWEDQENTPGKSA--NILYSKWLPQDDILAHPNIKLFINHAGKGGIT 382
            ...:.|.:.|.|. ..|||:||..:......  ||.::||:||..:||...:..|:.|||.|.|.
Worm   313 KIALKNAMEKFKNVTFIWKYEDDSSDEFAKGIENIHFAKWVPQTALLADSRLSAFLTHAGLGSIN 377

  Fly   383 ESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTL-EEKPFQEAILEILSNPQYAERVKSF 446
            |..|.|||.:..|...||.|||..:|:....:.||...| :.:....|...||.:..||:.....
Worm   378 ELSYLGKPAILCPQLFDQMRNAKMLVRHNGSIELSKYDLGDSEKIVNAFQAILFDSSYAKNALKL 442

  Fly   447 STLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKF 511
            :....::|:..:|..:...|:..|......|......|:||....||:..:..|:|::|:.:|..
Worm   443 AEQLENQPIKPKEMMVKHAEFAARFGRLPSLDPYSRKMTFIEYFLIDVAAISMVVLIAVVFVITK 507

  Fly   512 LVQFIYRRFISKPKKE 527
            :.:.:..:...|.|.|
Worm   508 MFKILCNKTSVKGKIE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	120/497 (24%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	123/516 (24%)
ugt-39	NP_504816.2	Glycosyltransferase_GTB_type	12..503	CDD:299143	125/514 (24%)
ugt-39	NP_504816.2	UDPGT	29..521	CDD:278624	123/515 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910