DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	157/536 - (29%)
Similarity:	272/536 - (50%)	Gaps:	46/536 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLK---PVVNHK 69
            |.|||:.  :::..|....||||||..:.||........:.|||.||:|.|::..:   |...:|
  Fly     8 FCLLALL--SLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYK 70

  Fly    70 NITVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMI-----RKNAETLMNDR-V 128
            :..   :|.|     .::|||..    ::.....|.|  ...::|.|     |::..|.::.| :
  Fly    71 DHL---LPPS-----TLTDTISL----EDFERPYSFL--FHYVEFFILHKMGREDCNTTLHSRAL 121

  Fly   129 RDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVL---ATMPPNHLLNPLIGNPLEVSYAGI 190
            .::..|....:|:::...|..|..:..|....||||.:   |.||.::   ...|.||..||  |
  Fly   122 TEILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHY---ERFGAPLIPSY--I 181

  Fly   191 SNPAEG-SKAVTFQRRLSSY--MQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSL 252
            |...:| |:.::|..||.::  :.||.. ::...:........::.:|  |.:|...::::||||
  Fly   182 SALFQGQSQEMSFAGRLGNWITVHSLNL-LYKMFTVPAGNALIRQRFG--PGLPSTEDLVRNTSL 243

  Fly   253 VFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLN 317
            :..:.|.:..|| :|..|:.||:||:.| ..|.|||.::.:.|.||..|.||:|.||.::...|:
  Fly   244 MLVNQHFSLSGP-KPLPPNVIEVGGVHI-SPPKPLPSDLQKILDNAPKGVILISWGSQLKACSLS 306

  Fly   318 PDTVAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGIT 382
            ......:...:.:|::.||||:|: :..|.|..|:...|||||.|||||||:|:|::|.|..|.|
  Fly   307 AARRDGIVKAIGRLEQEVIWKYEN-DTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTT 370

  Fly   383 ESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFS 447
            |:.....|::.:|::.||..|..|:|:.|..|.|.|..|:|....||:.:.| :|.:..|.|..:
  Fly   371 EAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVA 434

  Fly   448 TLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFL 512
            :.|.:|.....|:.::|.|:|....||...|...||:|.....::|:..::.:.|:..::.:..|
  Fly   435 SSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGL 499

  Fly   513 VQFIYRRFISKPKKEK 528
            ::...||   :||.::
  Fly   500 IRMFKRR---EPKGDR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	150/496 (30%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	145/503 (29%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	144/479 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454632
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	5.940