DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	127/514 - (24%)
Similarity:	250/514 - (48%)	Gaps:	42/514 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITVIQ---VPL--SKEEAQQMSDTIGAMSKN 96
            ||.:...:..:.||..||.|||:.....:::...:|.:|   :|:  ..|.|:...:.|..::.|
  Rat    34 SHWLNLKTILEELAARGHEVTVLKYPSIIIDQSKLTPLQFENIPVLYETEVAENHLNEIVNLAVN 98

  Fly    97 DNSNMAL---------SLLRMSDQMDFMIRKNA--ETLMNDRVRDLYLNRGNKFDLVISGYFMND 150
            ...|::|         ..|:::...:.:.|...  :|||| ::||.      |:|:::....:..
  Rat    99 VIPNLSLWEAARTLQDFFLQLTGNFEDLCRSTLYNQTLMN-KLRDA------KYDVMVLDPVIPC 156

  Fly   151 FQLGFARKVNAPVIVLATMPPNHLLNPLIGN-PLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLG 214
            .:| .|..:..|.:........:.:....|. |:.:||..:. ..|.:..:||..|:.:.|.||.
  Rat   157 GEL-VAEVLQIPFVNTLRFSMGYSMEKYCGQLPVPLSYVPVV-MGELTDHMTFTERVKNMMLSLF 219

  Fly   215 FGVFSHLSERRNRNW---YKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIG 276
            |..:  |.:.....|   |.:..|   :...:.:.:....:....::...|.| ||.:|:...:|
  Rat   220 FEFW--LQQYDFAFWDQFYSKTLG---RPTTFCKTVGKAEIWLIRTYWDIEFP-RPYLPNFEFVG 278

  Fly   277 GIQIKDKPDPLPQNIAEFLGNATD-GAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWE 340
            |:..| ...|||:.:.||:.::.: |.::.||||.:  |:|..:....:.:.|:::.::|:|::.
  Rat   279 GLHCK-PAKPLPKELEEFVQSSGEHGVVVFSLGSMI--KNLTEEKANLIASALAQIPQKVLWRYS 340

  Fly   341 DQE-NTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNA 404
            .:: .|.|.:..||  .|:||:|:|.||..:.||.|.|..||.|:.|||.||:.:|:|.|||.|.
  Rat   341 GKKPATLGPNTRIL--NWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPMFGDQPYNI 403

  Fly   405 NAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVI 469
            ..|...|..:.:::.|:.......|:..:::.|.|.|.....|.::.|:|:...:..::|.|:|:
  Rat   404 AHMEAKGAAVKVAINTMTSADLLSALRAVINEPSYKENAMRLSRVHHDQPVKPLDRAVFWIEFVM 468

  Fly   470 RHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRFISKPKKEK 528
            ||.||.||:.....:|:...:::|:...:.|.:|::..:|.....|:.|:...:.:|:|
  Rat   469 RHKGAKHLRVAAHDLSWFQYHSLDVIGFLLVCVVTLTFVITKCSLFMCRKCCLRERKKK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	119/474 (25%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	125/510 (25%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	125/504 (25%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	73/242 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.890