DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A3 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	147/547 - (26%)
Similarity:	269/547 - (49%)	Gaps:	53/547 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLAI-------AIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVT----- 60
            |||:.:       |.|.|:          ::|: ..||.|........||:.||.|||:.
  Rat     9 FLLIQLICYFRPGACGKVL----------VWPT-EYSHWINIKIILNELAQRGHEVTVLVSSASI 62

  Fly    61 VLKPVVNHK-NITVIQVPLSKEEAQ-QMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETL 123
            :::|..... |..:..|||||.:.: ..:..|...:::..:   ||:.....:|..:..:.::.:
  Rat    63 LIEPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFET---LSIWTYYSKMQKVFNEYSDVV 124

  Fly   124 MNDRVRDLYLNR-------GNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGN 181
            .| ..:.|..|:       |::||::::.......:| .|..:..|::......|.:......|.
  Rat   125 EN-LCKALIWNKSLMKKLQGSQFDVILADAVGPCGEL-LAELLKTPLVYSLRFCPGYRCEKFSGG 187

  Fly   182 -PLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGV-FSHLSERRNRNWYKEVYGNDPKMPEYS 244
             ||..||..:. .:|.|..:||..|:.:.:|.|.|.. |....|:....:|.:|.|....:   :
  Rat   188 LPLPPSYVPVV-LSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDVLGRPTTL---T 248

  Fly   245 EMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATD-GAILLSLG 308
            ||:....:....:....|.| .|.:|:...:||:..| ...|||:.:.||:.::.: |.::.|||
  Rat   249 EMMGKADIWLIRTFWDLEFP-HPFLPNFDFVGGLHCK-PAKPLPREMEEFVQSSGEHGVVVFSLG 311

  Fly   309 SNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQE-NTPGKSANILYSKWLPQDDILAHPNIKLF 372
            |.|  |:|..:....:.:.|:::.::|:|:::.:: :|.|.:.. || ||:||:|:|.||..|.|
  Rat   312 SMV--KNLTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTR-LY-KWIPQNDLLGHPKTKAF 372

  Fly   373 INHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNP 437
            :.|.|..||.|:.|||.|::.:|:|||||.|.|.||..|..:.:....|.......|:..::::|
  Rat   373 VAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDP 437

  Fly   438 QYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIC-FLIFVI 501
            .|.|.....|.::.|:|:...:..::|.|||:||.||.||:|.|..:|:...:::|:. ||:..:
  Rat   438 SYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLLCV 502

  Fly   502 LVSVLVLIKFLVQFIYRRFISKPKKEK 528
            :..|.::.||.: |..|:..:..||:|
  Rat   503 VGVVFIITKFCL-FCCRKTANMGKKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	136/506 (27%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	137/507 (27%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	141/529 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960