DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	145/572 - (25%)
Similarity:	252/572 - (44%)	Gaps:	98/572 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLAIAIGAVMG-SSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVV------------- 59
            |||...:..|:| |:..|..|.:.| :..||.:..:...:.|.:.||.|.|:
  Rat    12 LLLPCLLLCVLGPSASHAGKLLVIP-IDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSF 75

  Fly    60 -TVLK-PV-VNHKNITVIQVPLSKEEAQQ---MSDTIGAMSK-NDNSNMALS----LLRMSDQMD 113
             |:.| || ..::|:|...|.|.:....|   :...:...:| ..:|:|.||    ||..::.|.
  Rat    76 YTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCSHLLHNAEFMA 140

  Fly   114 FMIRKNAETLMNDRVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPL 178
            .:.:.:.:.|:.|.    :|..|:    :::.|.                    ::|..:.||.|
  Rat   141 SLEQSHFDALLTDP----FLPCGS----IVAQYL--------------------SLPAVYFLNAL 177

  Fly   179 IGNPLEVSYAGISNPA----------EGSKAVTFQRRLSSYMQSLGFG-----VFSHLSERRNRN 228
               |..:.......||          ..:..:.|.:|:.:.:.:|...     |:|.........
  Rat   178 ---PCSLDLEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSPYGSLATEI 239

  Fly   229 WYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAE 293
            ..|||...|        :|...|:....:....:.| ||.:|:.:.||||....| ..|.|....
  Rat   240 LQKEVTVKD--------LLSPASIWLMRNDFVKDYP-RPIMPNMVFIGGINCLQK-KALSQEFEA 294

  Fly   294 FLGNAT--DGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSA-NILYS 355
            :: ||:  .|.::.||||.|  ..:......::...|.::.:.|:|::..  ..|...| |.:..
  Rat   295 YV-NASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILV 354

  Fly   356 KWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLT 420
            |||||:|:|.||..:.||.|:|..||.|...:|.||:.:|:|.||..||..|...|.|:||::|.
  Rat   355 KWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLE 419

  Fly   421 LEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH-M 484
            :.....:.|:..:::|..|.|.:...|:|::|||:...:..::|.|||:||.||.||: |..| :
  Rat   420 MTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDL 483

  Fly   485 SFIAANNIDIC-FLIFVILVSVLVLIKFLVQFIYRRF-----ISKPKKEKTH 530
            ::...:::|:. ||:.::|..|.::.|.......:.|     :.|..|.|||
  Rat   484 TWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	133/524 (25%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	132/537 (25%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	133/543 (24%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	82/253 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960