DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-3

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_506203.2	Gene:	ugt-3 / 191174	WormBaseID:	WBGene00013903	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	143/568 - (25%)
Similarity:	247/568 - (43%)	Gaps:	87/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KFLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVL-------KP 64
            ::|||.    |....:.|.|.|.:.|....||:......|.:||:.|||||:...:       |.
Worm     2 RYLLLL----AFFPVAFGFNYLIISPVFGYSHMKFMGRIADILADAGHNVTLFQPIIYDYYAHKK 62

  Fly    65 VVNHKNITVIQVPLSKEEAQQMSDTI-------GAMSKNDNSNMALSLLRMSDQMDFMIRKNAET 122
            :|.:.||.||...:.:||....|:..       ...|||..|:..::..::..:.:.:.||   .
Worm    63 IVKNPNIEVINYEVDEEEKAAASEASVFKFFWKAKGSKNPISSAKITSEKLYKEFEHICRK---M 124

  Fly   123 LMNDRVRDLYLNRGNKFDLVIS------GYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPL--- 178
            |::..:....|::  .||..||      |.::.||     .|:.:|:             ||
Worm   125 LLDKELHRWILSK--NFDSHISEAFDFCGLYLGDF-----LKLKSPI-------------PLYSG 169

  Fly   179 ---------IGNPLEVSYAGISNPAEGS---KAVTFQRRLSSYMQSLGFGV-FSHLSERRNRNWY 230
                     :|.|:.::|.    |.|||   |..:...|||..:...|:.. |..|.:::....|
Worm   170 VRCGAASYAVGEPIPLNYL----PTEGSNYGKKSSAIDRLSDMLGLTGYHFQFGILFDKQYDQAY 230

  Fly   231 KEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPI----RPNVPSAIEIGGIQIKD-KPDPLPQN 290
            :...||   :..:.|:|::::  ||.:::   .|.    .|.:...|:|||..|:. |...|.:.
Worm   231 RLTGGN---VRTWQEILQSST--FFLTNS---NPYLSFSTPTISKVIQIGGFTIESFKTTTLDEE 287

  Fly   291 IAEFLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERV-IWKWEDQENTPGK--SANI 352
            ..:.| :..:..||:|.|:.:|...:..|....:.....::.:.. |||:|:.:.|...  |.|:
Worm   288 FNKIL-SLRNNTILVSFGTVIQSSDMPDDFKTGLIEAFRRMPDATFIWKYEEDDKTLKNKLSENV 351

  Fly   353 LYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLS 417
            :.|||:||..:||...:.||:.|.|.|...|..|.|...:.:|||:||..||..:.:.|..:...
Worm   352 VLSKWIPQPALLADSRLDLFVTHGGLGSTMEVGYAGVSSIMVPVFSDQGVNAEMLARHGGAIVYD 416

  Fly   418 LLTL-EEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPL 481
            ...| :.|...|.|..||:|..|.:..|..|.:..::||..::..|...|:..|.....:|:...
Worm   417 KFDLVDSKKLMETIQMILNNSDYRKNSKRLSDILHNQPMDPKQVLLNHCEFAARFAQVDNLEPYA 481

  Fly   482 VHMSFIAANNIDICFLIFVILVSVLVLIKF-LVQFIYRRFISKPKKEK 528
            ...:||....:|...|: |..:||:.|:.| ::.|:....|.|.|.:|
Worm   482 NKYNFIEFYCLDSLALV-VCTISVVALVMFKILSFVVNSVIEKLKLKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	131/527 (25%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	133/534 (25%)
ugt-3	NP_506203.2	egt	1..457	CDD:223071	125/494 (25%)
ugt-3	NP_506203.2	UDPGT	27..525	CDD:278624	133/534 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960