DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-16

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_506210.1	Gene:	ugt-16 / 191171	WormBaseID:	WBGene00013901	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	144/568 - (25%)
Similarity:	238/568 - (41%)	Gaps:	124/568 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVL-----KPVVNHKNITVI----QVP----L 78
            :|...|:...||.......:.:|.:.|::||::..:     |.:|..|.:..|    |.|    :
Worm    20 VLVFNPAFGASHANFLGKISDILIDAGNDVTMLIPIFVNGKKELVGSKKVKKIIRIDQDPRIAQI 84

  Fly    79 SKEEAQQ--MSDTIGAMSKNDNS------NMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNR 135
            .||.:.:  |..||..|.....|      |.:.:   .:.|.::|.::      .:.:..|   |
Worm    85 HKEGSTEEIMRKTIWKMDSAITSMFGFIGNFSKT---AAYQTEYMFQQ------TELIEQL---R 137

  Fly   136 GNKFDLVIS-GYFMNDF----QLGFARKVNA-PVIVLATMPPNHLLNPLIGNPLEVS-YAGISNP 193
            ..||||.|: ..|:..|    ::|....:|| ..:.:..|      ...:|.|..:| |.|:.:.
Worm   138 KEKFDLAITESLFLGAFALFDEIGIRSVINADSTLYMGGM------KGALGEPAAISYYPGLFSS 196

  Fly   194 AEGSKAVTFQRRLSS---YMQSLGFGVFSHLSE--------RRNRNWYKEVYGNDPKMPEYSEML 247
            .:..  :.|..|:.:   |:..|.|.|..:..|        :.:|:|              .|.|
Worm   197 IDDK--MNFFGRVKNAVGYLFGLWFSVLKYDDEIVAFPKSYKGSRDW--------------REHL 245

  Fly   248 KNTSLVFFSSHA----ASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNAT--------- 299
            .|.:..|.:|:.    ||     |.:|..:.:||:|:..|..          |.:|
Worm   246 SNVAFNFINSNQYIDYAS-----PTLPKTVFVGGMQVNTKKS----------GKSTLSKEWNDVL 295

  Fly   300 ---DGAILLSLGSNVQGKHLNPDTVAKMF-NVLSKLKERV-IWKWEDQENT-----PGKSANILY 354
               ...:|:|.|||.....: ||...|.| .|.:.:.|.. |||:|....|     |    |:..
Worm   296 SLRKTNVLVSFGSNAYSSDM-PDEFKKSFLEVFASMPETTFIWKYEVANATLVDHLP----NVKL 355

  Fly   355 SKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTL--S 417
            :.|:||:||||...:.|||.|.|.|...|..|.|||.:.:|:.|||||||:.:.:.|..|.|  :
Worm   356 TTWMPQNDILADDRLTLFITHGGLGSSVELAYQGKPAVVIPLMADQPRNAHMLTRHGGALQLDKT 420

  Fly   418 LLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLV 482
            .|...|| .:|||..:|::..|....:..:.:..|:|...::..|...::.::......|.|...
Worm   421 WLNNSEK-LREAIQTVLNDVSYKHNAERLAKILEDQPHKPKDVVLKHCDFAVQFGPLDTLNSEGR 484

  Fly   483 HMSFIAANNIDICFLIFVILVSVL----VLIKFLVQFIYRRF-ISKPK 525
            .::.....::||...|||||..:|    ::||.|.:|:.|.| |||.|
Worm   485 LLNTFQYYSVDIVLAIFVILSVILFVVYLVIKLLFRFLGRLFSISKRK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	126/526 (24%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	142/558 (25%)
ugt-16	NP_506210.1	UDPGT	19..532	CDD:278624	143/566 (25%)
		egt	<246..503	CDD:223071	77/277 (28%)
		HemY_N	483..>531	CDD:284604	16/47 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910