DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-47

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_505595.2	Gene:	ugt-47 / 187570	WormBaseID:	WBGene00011006	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	147/570 - (25%)
Similarity:	256/570 - (44%)	Gaps:	78/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VLRVEKFLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTV--LKP 64
            :.|....|||||......|.:.  .||...|:.|.||||.....|..||:.|||||::.:  |..
Worm     1 MFRYHSILLLAILYFFEYGLAY--KILVFSPATSKSHLISNGRIADELAKAGHNVTLLEIDFLGI 63

  Fly    65 VVNHKNI-----TVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKN---AE 121
            |.:.|:.     |:::||   ::.|...:.|.:.|:.          .|.|:..|.:.|.   .:
Worm    64 VDSTKSAKLVKKTIVRVP---KKMQGFKNVIQSFSEG----------VMEDEGLFELLKGNIAYQ 115

  Fly   122 TLMNDRVRDLYLN-------RGNKFDLVISGYF---MNDFQLGFARKVNAPVIVLATMPP--NHL 174
            |:.||...:...|       :...||    .:|   :|....|:|:.:......|.:..|  :|:
Worm   116 TVYNDLCEEFLENEVMFNKLKDENFD----AFFAEQLNICGFGYAKALGIQRKFLISSCPFFSHV 176

  Fly   175 LNPLIGNPLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPK 239
            .: ...:|  ..||.:...::.|...|:..|.::.::.:....|.:.|..|..:.:::.:|:|
Worm   177 YD-YTSHP--APYASVPFISDMSPEPTYLERTNNLLRGITINTFFYFSHNRLTSIFRKKFGDD-- 236

  Fly   240 MPEYSEMLKNTSLVF--------FSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLG 296
            .|..:|:::|..::|        |||         |.:|:.:.:||:.:.|....:.......:.
Worm   237 FPAITEIVRNVDIIFLATDEIIDFSS---------PTLPNLVHVGGLGVDDDTTEMGPVFEAEMK 292

  Fly   297 NATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKER--VIWKWEDQENTPGKS---ANILYSK 356
            ....|.|..|||:......::...:.....::.|..:.  :|...::.:||..|:   :|:..|.
Worm   293 KGDKGVIYFSLGTIANTSTIDKKVMESFLEIVKKFPDYHFLIRADKNDKNTKDKATEISNVFVSD 357

  Fly   357 WLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGL---TLSL 418
            ||||..||.||.::.||.|||..|:.|:...|.|::::|...||..|:.|:.|.|:|:   ....
Worm   358 WLPQPAILHHPRLRTFITHAGYNGLMEAALAGVPLITIPFMFDQNLNSRAIEKKGWGIRRDKKQF 422

  Fly   419 LTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH 483
            || |....:|||.|:|:||.|.::......|.|::||.||:.|:..||:||::.|...|.:....
Worm   423 LT-EPNAIEEAIREMLTNPSYTKQAHRVRDLMRNKPMGARDRFIKTTEWVIQNGGVHELLTEGRD 486

  Fly   484 MSFIAANNIDI---CFLI---FVILVSVLVLIKFLVQFIYRRFISKPKKE 527
            :|.|...|:||   ||.:   |:|.....:...|.....:....||.||:
Worm   487 LSIIKYYNLDIIVPCFFVAFYFIIFPFFKLFGGFYYYSCFGHIESKYKKD 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	135/525 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	134/532 (25%)
ugt-47	NP_505595.2	UDPGT	23..527	CDD:278624	136/535 (25%)
ugt-47	NP_505595.2	egt	<230..509	CDD:223071	82/290 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14096
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910