DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-19

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_500912.2	Gene:	ugt-19 / 187129	WormBaseID:	WBGene00019515	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	139/530 - (26%)
Similarity:	236/530 - (44%)	Gaps:	69/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHLIIQMSAAKVLAENGHNVTVV---------TVLKPVVNHKNITVIQVPLSKEEAQQMSDTIGA 92
            ||:....:||.:|.:.|||||||         |.||   :.|||..:          ..||.:.|
Worm    32 SHVKFLGAAADILTDAGHNVTVVMPVFDDSIKTSLK---STKNIIFV----------NSSDDVAA 83

  Fly    93 MSK-----------NDNSNMALSLLR---MSDQMDFMIRK---NAETLMNDRVRDLYLNRGNKFD 140
            .:|           .||:|....|.|   ||:......:|   |.|.:...:..:..|.....||
Worm    84 FAKARTKMLNNLWTMDNTNPFTMLTRVGMMSNTFSSQCKKVLTNTELIETMKAENYDLAVTEPFD 148

  Fly   141 LVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNP---AEGSKAVTF 202
            |....:|.       |..:.|.|.:|::...:| ::.:||.|...||    ||   :..|..:|.
Worm   149 LCAYPFFE-------AINIRAHVGILSSSRLDH-VSDVIGQPAAPSY----NPGLMSTNSDRMTM 201

  Fly   203 QRRLSSYMQ-SLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIR 266
            .:|..:.:| :.|...||::.: |.....||:   :||...:.|::...|.:..:.....:.| .
Worm   202 WQRFVNVIQYACGSYFFSYIGD-REAEVVKEI---NPKWRSWREVVPEASFIMTNQIPLLDFP-A 261

  Fly   267 PNVPSAIEIGGIQIK-DKPD-PLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLS 329
            |.....|.|||:.:| ||.. .|.:..::.| :.....:.:|.|||.:...:..:.......|:.
Worm   262 PTFDKIIPIGGLSVKTDKKSLKLEEKWSKIL-DIRKKNVFISFGSNARSVDMPLEYKNTFLQVIK 325

  Fly   330 KLKERV-IWKWEDQEN--TPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPM 391
            .:.:.. |||:||..:  |.| ..|:....||||:::||...:.:|:.|.|.|.:||....|.|.
Worm   326 SMPDTTFIWKYEDLNDKFTEG-IENVYLGDWLPQNELLADKRLNVFVTHGGLGSVTELSMMGTPA 389

  Fly   392 LSLPVFADQPRNANAMVKSGFGLTLSLLTLEE-KPFQEAILEILSNPQYAERVKSFSTLYRDRPM 455
            :.:|:||||.||...:.:.|....|....|.: |..|..|.|:|:||:|.:..:..:.:.|::|.
Worm   390 VMIPLFADQSRNGQMLKRHGGVAVLKKTDLSDAKLVQSTIEEVLNNPEYRKSAERVAEMLRNQPT 454

  Fly   456 TARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVL-VLIKFLVQFIYRR 519
            ..:|:||.:.|:..|......:.:....::|:....:||..:|.:|.|..| :..|.:...|.:.
Worm   455 NPKETFLKYVEFTARFGKLPSMDNYGRQLTFVQYFFLDIISIISLITVVFLYISYKVIRCTIKKC 519

  Fly   520 FISKPKKEKT 529
            |.|:..:||:
Worm   520 FGSRSSEEKS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	127/488 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	137/525 (26%)
ugt-19	NP_500912.2	egt	1..472	CDD:223071	126/471 (27%)
ugt-19	NP_500912.2	UDPGT	32..521	CDD:278624	135/520 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910