DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A3 and H23N18.4

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504314.2	Gene:	H23N18.4 / 186769	WormBaseID:	WBGene00019235	Length:	483	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	113/480 - (23%)
Similarity:	208/480 - (43%)	Gaps:	47/480 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LRVEKFLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVV----TVLK 63
            :.:...:.|...||.:...|    ||...|....||:......|.::|::|||||:.    ..||
Worm     1 MHLNSIIFLFFIIGLISCKS----ILIFNPIFGFSHVKFISKMADIIADHGHNVTLFQPFHLALK 61

  Fly    64 ---PVVNHKNITVIQV------PLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKN 119
               .:|.::||.:|..      .|.|.|.:.......:...|   |..|....|.:.|:....|.
Worm    62 NADKLVKNQNIKIINYYPDHYDELLKTEKKTFPMLWDSQLMN---NPILCSFMMPNIMEDSWEKT 123

  Fly   120 AETLMNDR--VRDLYLNRGNKFDLVISGYF-MNDFQLGFARKV-NAPVIVLATMPPNHLLNPLIG 180
            |..|:.|:  :.||   :..|||:|:|..| :....|.:..:: |.|::......|   .|...|
Worm   124 ATQLLKDQKVIEDL---KNQKFDVVLSETFELTGIYLAYLLEIPNIPIMSAVRFVP---YNEAFG 182

  Fly   181 NPLEVSYAGISNPAEGSKAVT---FQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPE 242
            .|..|.|.    |.:||:...   |..||:...::..:.:....:.:....:.::..|.  .:|.
Worm   183 QPSTVGYI----PQQGSQLAPEAGFLDRLNDVYRNYFYTLTMKRASQLQNTFIEKAIGR--PVPN 241

  Fly   243 YSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIK-DKPDPLPQNIAEF--LGNATDGAIL 304
            :.:::..:.:...:|:...:..: |...:.:.:|||.|. :|...:.....|:  :....:..:|
Worm   242 WKDLVTRSPIYITNSNPYLDFAV-PTTATIVHVGGITIDLEKMRHVAALTEEYENIFAERESTVL 305

  Fly   305 LSLGSNVQGKHLNPDTVAKMFNVLSKLKE-RVIWKWE--DQENTPGKSANILYSKWLPQDDILAH 366
            :|.||.::...:..:..|.:.|:...|.| ..|||:|  |.|.......|:....|:||..:||.
Worm   306 ISFGSVIRSYEMPDNFKAGIINMFKSLPEVTFIWKYEKDDVEFQKRLPKNVHLKNWVPQPSLLAD 370

  Fly   367 PNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEE-KPFQEAI 430
            ..:|||:.|.|.|...|..|.|||.|.:|:|.|||:||:.:.:.|..:......|.: ....:.:
Worm   371 KRLKLFVTHGGLGSTMEVAYTGKPALMIPIFGDQPQNADMLSRHGGAVAYDKFELADGDKLIKIV 435

  Fly   431 LEILSNPQYAERVKSFSTLYRDRPM 455
            .:::|||:|.:..:....:..::|:
Worm   436 KDMVSNPKYEKNAQELLRVLSNQPI 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	113/480 (24%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	106/446 (24%)
H23N18.4	NP_504314.2	GT1_Gtf-like	21..466	CDD:340817	109/456 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960