DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-32

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504060.2	Gene:	ugt-32 / 185911	WormBaseID:	WBGene00018543	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	134/559 - (23%)
Similarity:	234/559 - (41%)	Gaps:	92/559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITVIQVPLSKE 81
            :|..::....:|...|:.:.||.......|..|.|.|||||..|   |:::........|.|:|:
Worm    12 SVFSNTDSLRVLVYSPAYAASHTNFMARLADTLTEAGHNVTFFT---PIIDESRKDQFGVKLTKD 73

  Fly    82 EAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDR----VRDLYLNRGN----- 137
                                 :.:|...:|    :::|..|:.||.    ..|:....|:
Worm    74 ---------------------VLILEQDEQ----VKRNPVTIDNDMKYFWTTDVTSANGHKVMGT 113

  Fly   138 -------------KFDLVISGYFMNDFQLGFA-----------RKVNAPVIVLATMPPNH-LLNP 177
                         |...:|......::.:|.|           |.:....::|.|...|: :|.|
Worm   114 LHKQAIFTCENVFKHQELIDELRSRNYDIGLAEPLMTCGLALFRHIGIEKVMLTTSCTNYDILLP 178

  Fly   178 LIGNPLEVSYAGISNPAEGSK---AVTFQRRLSSY-MQSLGFGVFSHLSERRNRNWYKEVYGNDP 238
            ..|.|.:.||    ||:..|:   .::|.:||.:| :..:....|..:.: ...|.|::..|.
Worm   179 ATGEPEDTSY----NPSMNSQVTDVMSFWQRLENYDLYHVMIPTFETIFD-DEANVYRKYLGE-- 236

  Fly   239 KMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGA- 302
            ..|::.:::.:.||.|.:|....:.| ||::...||||||.:..:..| |.|  |...|..|..
Worm   237 SFPDWRDLIPDASLHFTNSIPFLDFP-RPSIQKTIEIGGIAVDIESIP-PVN--EEFSNILDKRP 297

  Fly   303 --ILLSLGSNVQGKHLN---PDTVAKMFNVLSKLKERVIWKWE-DQENTPGKSANILYSKWLPQD 361
              :|:|.||..:...:.   .:.:.::|.  |:.....|||:| |.........|:::.||:||.
Worm   298 MNMLISFGSLARSTEMPIIFKENLLRVFQ--SEPNCTFIWKYESDDVAFANDVENVIFVKWMPQT 360

  Fly   362 DILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEE-KP 425
            .||....:..|:.|.|.|...|:.:.|||.:..|:||||.||:|.:.:....:.|....|.. :.
Worm   361 AILKDNRLTAFLTHGGLGSTNEAAFLGKPSVMFPIFADQSRNSNMLGRQEMSIVLHKSDLGNFQK 425

  Fly   426 FQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAAN 490
            .::|..|||.|.:|....:..:.:.|::|...|:.|:...|:|.|.....|:....:.|.|....
Worm   426 IRDAFHEILHNEKYHLNARKVADMVRNQPAKPRDIFVKHVEFVGRFGPLHHMTPYSLKMPFYQRY 490

  Fly   491 NIDICFLIFVILVSVLVLIKFLV---QFIYRRFISKPKK 526
            :.||  .||..|.:..:.:.||:   :.|:.:|..|..|
Worm   491 HYDI--FIFKFLTNYFIPVVFLLCVTKLIFSKFQLKKIK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	123/518 (24%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	130/537 (24%)
ugt-32	NP_504060.2	Glycosyltransferase_GTB_type	1..508	CDD:299143	128/538 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910