DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-42

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_503278.2	Gene:	ugt-42 / 185168	WormBaseID:	WBGene00017959	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	150/567 - (26%)
Similarity:	233/567 - (41%)	Gaps:	112/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHK--NI 71
            ||:.:....::.:..|.|.|.:.|:...||.......|..|.|.||||||:::   :|:.|  ||
Worm     3 LLILLIFVFLISNISGFNYLVVSPAFGHSHSTFMGKLADALTEAGHNVTVLSI---IVSSKFRNI 64

  Fly    72 T-------VIQVPLSKEEAQQMSDTIGAMSKNDNSN-------------MALSLLRMSDQMDFMI 116
            :       ::.|..:.|:.||..:    |..||.|.             ..|...:|||......
Worm    65 SYTKLTKDIVVVETTNEQDQQAEN----MENNDFSRYWTQEGTLLETIPSYLMFTKMSDHGYETF 125

  Fly   117 RKNA----ETLMNDRVR------DLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIV-LATMP 170
            |.:|    |.|.:.|.|      :.||:.|.    .|..|            :..||.: :.::.
Worm   126 RNHALPQMEYLKSHRPRYDAVFFESYLHTGK----AIQEY------------LEIPVFLPVTSLT 174

  Fly   171 PNHLLNPLIGNPLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSER----------- 224
            .::.|..|||.|:..||                  ||.|..:  ||...:..||
Worm   175 HDYRLAELIGEPVSPSY------------------LSGYFTN--FGNIMNFQERVINTLSYYLAQ 219

  Fly   225 ---RNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQI------ 280
               .:.|| |.:......:...||..: ...||.:|:...:.| ||.:...||||||.:
Worm   220 ILISSPNW-KTLQDPSKDLLVESEYYR-APYVFINSNPYIDFP-RPLLSKTIEIGGITVDADALK 281

  Fly   281 KDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPDTVA-KMFNVLSKLKE-RVIWKWEDQE 343
            .:|.|....||.:    .....:|:|.|:..:..|: ||:.. .|..|:...|. ..|||:|.:|
Worm   282 SEKVDETWNNILK----RRPHNVLISFGTMFKSIHM-PDSYKNNMVKVMKSFKNVTFIWKYESEE 341

  Fly   344 NTPGKSA-NILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAM 407
            .:....| ||::.||.||..:||...:..|..|.|.|.:.|..|.|||.|..|:||||.||:..:
Worm   342 TSFANGAENIIFKKWTPQTALLADSRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQVRNSKML 406

  Fly   408 VKSGFGLTLSLLTLEE-KPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRH 471
            .:....:.:|...||. ...:.|:..||.:..|||..:..:.....:|...:|.|:...|:..|.
Worm   407 SRHNGSIEISKFNLESYNTLRSALHSILFDESYAENAEKLAKKLEFQPAKPKELFVRHAEFAARF 471

  Fly   472 HGAAHLQSPLVHMSFIAANNID--ICFLIFVILV--SVLVLIKFLVQ 514
            .....|...|..|.|...:.:|  :|...||:||  |::|:|:.:||
Worm   472 GEQPALDCNLRTMGFATYHLLDVVVCLTSFVVLVILSLVVIIRKIVQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	139/537 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	144/539 (27%)
ugt-42	NP_503278.2	Glycosyltransferase_GTB_type	14..501	CDD:299143	139/537 (26%)
ugt-42	NP_503278.2	UDPGT	22..495	CDD:278624	136/523 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910