DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-38

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504812.1	Gene:	ugt-38 / 184294	WormBaseID:	WBGene00017333	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	136/547 - (24%)
Similarity:	234/547 - (42%)	Gaps:	53/547 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHK---- 69
            ||||: :..:..:....|.|...|..:.||.....:.|..|.:.||||...|   |::..|
Worm     2 LLLAL-LFTLYANVSSFNFLVFCPLFAHSHSKFFATIADSLTDAGHNVAFFT---PIIVEKYRNF 62

  Fly    70 NIT-----VIQVPLS---KEEAQQMS--DTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLM 124
            |.|     |:.:..|   ||..:|||  |.:...:::..:...::::|:..:|    .....|:|
Worm    63 NYTKSTKDVVYMEPSKKLKEYGRQMSTGDFVRYWTEDSTATEIITVVRIFQKM----YNEQGTVM 123

  Fly   125 NDRVRDLYLNRGNKFDLVI------SGYFMNDFQLGFARKVNAPVIVLA-TMPPNHLLNPLIGNP 182
            .|.:..|...:..|||::|      |.|.:.|:       :..|..:.: ::..:..|...||.|
Worm   124 KDNIEILNDLKKRKFDVIIFEAFIFSAYPLMDY-------LEIPTFIPSLSVAHDTALAVEIGEP 181

  Fly   183 LEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEML 247
            :..|.........|.|....:|..:::|......:..:.:.|..:..|..:        :...::
Worm   182 VMPSVVSDCLSPFGDKLSITERAFNAFMVPYFDFMIGYPTHRSFKPPYNPI--------DIRSIV 238

  Fly   248 KNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKD---KPDPLPQNIAEFLGNATDGAILLSLGS 309
            ...|.||.:|:...:.| ||.:...|:||||.:..   :...|.:..:|.| ...:..:|:|.||
Worm   239 PEASFVFLNSNPFVDFP-RPTLTKTIQIGGISVDSNELRSQKLDETWSEIL-KLREKTMLVSFGS 301

  Fly   310 NVQGKHLNPDTVAKMFNVLSKLKE-RVIWKWEDQENTPGKSA--NILYSKWLPQDDILAHPNIKL 371
            .:..|.:.......:.|.:.|.|. ..|||:||..:......  ||.::||:||..:||...:..
Worm   302 MLYSKDMPFKNKIALKNAMEKFKNVTFIWKYEDDSSDEFAKGIENIHFAKWVPQTALLADSRLSA 366

  Fly   372 FINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTL-EEKPFQEAILEILS 435
            |:.|||.|.|||..|.|||.:..|...||.||...:|:....:.||...| :.:...||...||.
Worm   367 FLTHAGLGSITELSYLGKPAILCPQLFDQMRNTKMLVRHNGSIELSKYDLGKSEKIIEAFQAILF 431

  Fly   436 NPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFV 500
            :..||:..:..:....::|:..:|..:...||..|......|......|||:....:|:..:...
Worm   432 DSSYAKNAQKLAEQLENQPIKPKEMMVKHAEYAARFGRLPSLDPYSRKMSFVEYFLLDVAAICVF 496

  Fly   501 ILVSVLVLIKFLVQFIYRRFISKPKKE 527
            ||..|:.::..|||.::..|:.|.|.|
Worm   497 ILTFVVFVVTKLVQSLFDIFLIKRKTE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	125/508 (25%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	127/516 (25%)
ugt-38	NP_504812.1	Glycosyltransferase_GTB_type	12..512	CDD:299143	128/523 (24%)
ugt-38	NP_504812.1	UDPGT	29..521	CDD:278624	127/515 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910