DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-36

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504820.2	Gene:	ugt-36 / 184266	WormBaseID:	WBGene00017315	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	140/548 - (25%)
Similarity:	233/548 - (42%)	Gaps:	73/548 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITVIQVPLSKEEAQQM 86
            |...|.|...|....||.......|..|...|||||..|   |.:..| .:.||...|.....|:
Worm    20 SDSYNFLVFCPLFGHSHTTFFAKIADTLTYAGHNVTFFT---PTIVRK-FSKIQYVKSITHVLQL 80

  Fly    87 SDT-----IGAM------SKNDNSNMALS-LLRMSDQMDFM-------IRKNAETLMNDRVRDLY 132
            ..:     :|:|      ||....:.:|| :|.|.|..:.|       |.:|...|  |.::::
Worm    81 DPSDRLVKLGSMFEEKDVSKFWYRDSSLSEMLPMIDTFNNMFVEQAAVISRNLHVL--DDLKEM- 142

  Fly   133 LNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNPAEGS 197
                 .||::|..:|:....|..........|...::..::.:...||.||.:|...:.. :|.|
Worm   143 -----NFDVMIFEHFVEPAYLVLDYLEIQKFIPATSLAFDYNMVKSIGEPLMLSTVPLPT-SEYS 201

  Fly   198 KAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNT-------SLVFF 255
            ..::..:||.:.:..|   :|.:|..:.....|:         |.|:.:  ||       |.||.
Worm   202 DRMSLPQRLINAINPL---IFDNLIPKNKYRSYR---------PPYAPI--NTKSIEPFCSAVFT 252

  Fly   256 SSHAASEGPIRPNVPSAIEIGGIQIK-DK-PDPLPQNIAEFLGNATDGAILLSLGSNVQGKHL-- 316
            :|:...:.| |..:...:::|||.:. || ......|..:.:.|.....:|:|.||.:..|.:
Worm   253 NSNPYIDYP-RATLEKNVQVGGISVDIDKLKSQKVSNEWDAVLNLRPKTVLVSFGSIMLSKDMPI 316

  Fly   317 -NPDTVAKMFNVLSKLKE-RVIWKWEDQENT-PGKSANILYSKWLPQDDILAHPNIKLFINHAGK 378
             |..|:|   .||.|..: ..|||:|..:.: ...:.||.:|.|:||..:||.|.:..|..|||.
Worm   317 NNKITIA---TVLGKFPDVTFIWKYETNDTSFANGTENIHFSNWVPQTALLADPRLSAFFTHAGL 378

  Fly   379 GGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEE-KPFQEAILEILSNPQYAER 442
            |.:.|..|.|||.:..|:||||.|||..:.:....:.:|...|.. ...:||:.:||.:..|...
Worm   379 GSVNEVSYLGKPTIMCPIFADQMRNAKMLARHNGSIEISKYDLSNGDKIEEALSKILFDESYKTA 443

  Fly   443 VKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVH---MSFIAANNIDICFLIFVILVS 504
            .:..:....::|:..:|..:...|:..:.   .||.|...|   ||||....||:..:|...::.
Worm   444 AEKLAHQLANQPVKPKELLVRHAEFAAQF---GHLPSLDPHSRQMSFIQYFLIDLTAIILSTVIL 505

  Fly   505 VLVLIKFLVQFIYRR--FISKPKKEKTH 530
            .|.::..|.:.:|.:  |.....|:||:
Worm   506 FLFVLFKLGKLMYSKLPFNLSLVKQKTN 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	130/504 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	133/527 (25%)
ugt-36	NP_504820.2	Glycosyltransferase_GTB_type	6..507	CDD:299143	133/520 (26%)
ugt-36	NP_504820.2	YjiC	25..455	CDD:224732	117/460 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910