DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-43

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001255487.1	Gene:	ugt-43 / 184052	WormBaseID:	WBGene00008485	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	148/568 - (26%)
Similarity:	253/568 - (44%)	Gaps:	83/568 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLAIA--IGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPV-VNHK 69
            ||||.:|  ..:|..:.:|..:|...|....|||....:.:.:|.|.|:|||::..|..: :|:.
Worm     8 FLLLILASFCFSVSNNIKGKKVLVYLPVTGHSHLKFMSTTSNILQEEGYNVTLLLPLIDITLNNT 72

  Fly    70 NITVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRV------ 128
            ||.:::                .:....|.::...::|...:|..|..:.....|...:
Worm    73 NIPIVK----------------KIKHRINLDIHPGVMRTIIKMGGMASRRQTWTMGSGIYGFDGI 121

  Fly   129 ----RDLYLN---------------RGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNH- 173
                .|||.|               :..|:::.:|..|   |..|||...:..:..:.:: .:|
Worm   122 SHLLSDLYSNICDNIFHMPGLLDRLKAEKYEMGMSEPF---FVCGFALFDHLGIDKIISV-DSHI 182

  Fly   174 -LLNPLI--GNPLEVSYAGISNPA---EGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKE 232
             |..|.|  |.|:..||.    ||   |.|..::|..|..|..::.....|:.|...:..:..|.
Worm   183 GLEGPKIAHGFPVTSSYL----PAAFSESSDHMSFVERTRSLYETYLNRKFARLIHNKEIDAMKG 243

  Fly   233 VYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDK--PDPLPQNIAEFL 295
            ||..   ...:.|:::..:.:|.:|:...:.|. |.....||||||...:|  .:.||::....|
Worm   244 VYKG---KSTWEELMRLPAYMFTNSNPILDFPY-PRPSKFIEIGGIAADEKKHDEVLPESYDHIL 304

  Fly   296 GNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERV--IWKWED------QENTPGKSANI 352
             |..:..:|:|.|||.:...: ||.:.:...:...:...:  |||:|:      :|..| ...||
Worm   305 -NLRNRTVLISFGSNAKSIFM-PDHMRRSLIIALGMMPDITFIWKYENSSIDIVKEFDP-TIKNI 366

  Fly   353 LYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLS 417
            :...|:||..:||.|.:.||:.|.|.....|..:.|||.:.:|||.||.||:..:.:.|..|.|.
Worm   367 VQVDWMPQQALLADPRLDLFVTHGGMASTNEIAFSGKPAVMVPVFGDQTRNSRMLERHGGVLMLR 431

  Fly   418 LLTLEEKPFQ-EAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPL 481
            ...||..... |.||.:|::|.||||.:..:||.|:.|.:.::.||.:..:|.|......:.|..
Worm   432 KENLEYPEIVIETILSVLNDPSYAERAQQLATLLRNHPESPKQVFLKYFNFVARFGKPTGIDSNS 496

  Fly   482 VHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRF--ISKPKKE 527
            :::.|||...:|:  :.|:::|:...  ||||..:|..|  :.|.|.|
Worm   497 INVDFIAYYYLDL--IAFLLIVAYFA--KFLVSHVYSYFCYLRKEKAE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	136/527 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	137/534 (26%)
ugt-43	NP_001255487.1	Glycosyltransferase_GTB_type	<215..517	CDD:299143	87/310 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910