DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-33

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_505692.2	Gene:	ugt-33 / 179464	WormBaseID:	WBGene00007946	Length:	522	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	137/567 - (24%)
Similarity:	239/567 - (42%)	Gaps:	110/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVV--NHKN 70
            ||.....:|.|    |..|.|...|..:.||.......|..|.:.|||   ||.|.|:|  .::|
Worm     6 FLCTLFLVGFV----QPFNYLVFCPLYAHSHHKFLAKIADTLTDAGHN---VTFLAPIVLRKYEN 63

  Fly    71 I-------TVIQVPLSKE-EAQQMSDTIGAMSKNDNSNMAL-----SLLRMSDQMDFMIRKNAET 122
            :       .::.:..||| ||...:.........|.:.:..     :.::|..|:...::|:...
Worm    64 VKYLESTKDIVYIQPSKELEALGFTSNYSKFWTEDATAIQFVPAVRTFVKMFVQLYEDLKKDLSV 128

  Fly   123 LMNDRVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHL-LNPLIGNPLEVS 186
            |      |...||  .||.::. .|:.......|..:....::.:....:|. ::..||.|
Worm   129 L------DELKNR--NFDAIVF-EFLCPTAFPIAEYLGIKALLPSLSMTHHTQMSRWIGEP---- 180

  Fly   187 YAGISNP-------AEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYS 244
                |:|       :.....:.|..||.:.:..:.|.:|..:                |:|..:|
Worm   181 ----SSPTVLPSMISSFGDDMNFWERLGNTLGDVFFTLFVDM----------------PRMTSFS 225

  Fly   245 ---------EMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGI-----QIKDKP--DPLPQNIAE 293
                     ||......:|.:|:...: ..||.:...:.||||     |:|.|.  :...:.|:|
Worm   226 DPERKIDFYEMSVRAPFMFMNSNPYLD-YARPILTKTVLIGGISVNVTQLKQKKLNEKYDKIISE 289

  Fly   294 FLGNATDGAILLSLGSNVQGKHLNPDT-------VAKMF-NVLSKLKERVIWKWEDQENTPGKS- 349
            ...|     ||:|.||.:..|.: ||.       |.|.| ||      ..|||:|:.:.:..|.
Worm   290 RQQN-----ILISFGSMIFSKDM-PDVYKNTLVQVIKSFPNV------TFIWKYEEDDVSFAKHL 342

  Fly   350 ANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGL 414
            .|:.:|||:||..:||...:..|:.|||.|.:||..|.|||.:.:|:||||.||:..:.:....:
Worm   343 PNLHFSKWVPQTALLADSRLSAFVTHAGLGSVTELSYMGKPAVLIPLFADQLRNSKTLSRHNGSI 407

  Fly   415 TLS---LLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAH 476
            |||   |.:.|:..|  ||..||::.:|....:..|...:|:|::.....:...|:..::....:
Worm   408 TLSKYDLSSFEKLRF--AINTILNDERYKINAEILSQQLQDQPVSPHALLVKHAEFGAKYGELPN 470

  Fly   477 LQSPLVHMSFIAANNIDIC----FLIFVILVSVLVLIKFLVQFIYRR 519
            |......||||:...:||.    |::....:.:::.:|::::|.:::
Worm   471 LDPCSRQMSFISFYMLDIIVFVGFILITTTIGIVLTVKWILKFCFKQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	132/532 (25%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	129/538 (24%)
ugt-33	NP_505692.2	Glycosyltransferase_GTB_type	1..498	CDD:299143	135/546 (25%)
ugt-33	NP_505692.2	UDPGT	31..520	CDD:278624	129/538 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14625
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910