DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt-22

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_502633.1	Gene:	ugt-22 / 178330	WormBaseID:	WBGene00007455	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	143/552 - (25%)
Similarity:	249/552 - (45%)	Gaps:	55/552 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLL-LAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNH--- 68
            ||| |.:.:|:.:|.::...||........||:.:..:.:..|.:.||:   :|||.||::.
Worm     6 FLLPLLLLLGSFVGLTEPYKILMYTNLFGHSHIKMLGAVSDTLTDAGHD---LTVLMPVIDFKQE 67

  Fly    69 --------KNITVIQVPLSKEEAQQMSDTIGAMSK-------NDNSNMALSLLRMSDQMDFMIRK 118
                    |||..||      ..|.:|.||..|.|       .|||| .|.::..:..|..:...
Worm    68 NKTAMKSTKNIIKIQ------PGQDISKTIETMEKFMTQLWTTDNSN-PLFMVFHAPAMSAIFAS 125

  Fly   119 NAETLMNDR--VRDLYLNRGNKFDLVISGYFMN-DFQLGFARKVNAPVIVLATMPPNHLLNPLIG 180
            ....::.|:  :..|   |...|||.|:..|.. .:.|..|.|:.|.|.||:....:| ::..||
Worm   126 QCRKVLEDKELIERL---RAENFDLAITEPFDTCAYALFEAIKIRAHVAVLSCSRLDH-VSKAIG 186

  Fly   181 NPLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSE 245
            .|:..||...:....|.:...:||.::.....:|..:||::.: .:....||:.   |.:..:.|
Worm   187 QPIAPSYVPGTQSTHGERMTIWQRFMNILHFLMGDFLFSYIGD-EDFKVAKEII---PGVRSWRE 247

  Fly   246 MLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIK--DKPDPLPQNIAEFLGNATDGAILLSLG 308
            :|...|.:|.:.....:.| .|.....|.||||.:|  .|...||:...:.||..... ||:|.|
Worm   248 VLPEASFIFTNHIPLMDFP-APTFDKIIPIGGISVKTQKKSLELPEKWNKILGLRKKN-ILVSFG 310

  Fly   309 SNVQGKHLNPDTVAKMFNVLSKLKERV-----IWKWEDQENTPGKSA-NILYSKWLPQDDILAHP 367
            ||.:...: |:...:  ||| |:.|.:     |||:|::::|..... |:....||||:::|..|
Worm   311 SNARSADM-PEHFKQ--NVL-KVAESMPDVTFIWKYENEKDTLADHLDNVYLGDWLPQNELLGDP 371

  Fly   368 NIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTL-EEKPFQEAIL 431
            .:.||:.|.|...:||....|||.:.:|:||||.||||.:.:.|....|....| ..:..:..|.
Worm   372 RLSLFVTHGGLASVTELALMGKPAVMVPLFADQARNANMLKRHGGAAVLHKTDLGNAETIRNTIK 436

  Fly   432 EILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICF 496
            ::|.|.:|....:..:.:..::|...:::.:...|:..:......:.....|.|:|....:||..
Worm   437 KVLENEKYRVNAERLAEMLNNQPTNPKDTLIKHVEFAAKFGQLPSMDPYGRHQSYIEYYLLDIIS 501

  Fly   497 LIFVILVSVLVLIKFLVQFIYRRFISKPKKEK 528
            :..|::::...:...|::..:|......|.:|
Worm   502 IALVLILTTSFISFQLIKCTFRMCCGSGKVKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	136/512 (27%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	133/518 (26%)
ugt-22	NP_502633.1	UDPGT	36..530	CDD:278624	133/517 (26%)
ugt-22	NP_502633.1	egt	<256..515	CDD:223071	71/264 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14115
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910