Protein Alignment Ugt37A3 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 130/532 - (24%)
• Similarity: 243/532 - (45%)
• Gaps: 67/532 - (12%)

  Fly    33 SLSPSHLIIQMSAAKVLAENGHNVTVV----TVL------KPVVNHKNITVIQVPLSKEEAQQMS 87
            :|..||.:......:.|.:..|||||:    |:.      .||    |..||.|...|.....:.
Human   237 ALDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPV----NFEVIPVSYKKSNIDSLI 297

  Fly    88 D--------------TIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRGNK 138
            :              ||.|..| :...:..:..:::.|:...:.||.:.:..       |.:|.
Human   298 EHMIMLWIDHRPTPLTIWAFYK-ELGKLLDTFFQINIQLCDGVLKNPKLMAR-------LQKGG- 353

  Fly   139 FDLVISG--YFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGN-PLEVSY--AGISNPAEGSK 198
            ||::::.  ....|.   .|.|:..|.:......|...:....|. |..|||  |.:|   |.:.
Human   354 FDVLVADPVTICGDL---VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALS---ELTD 412

  Fly   199 AVTFQRRLSSYMQSLGFGVFSHLSERRNRNW---YKEVYGNDPKMPEYSEMLKNTSLVFFSSHAA 260
            .:||..|:.:   ::.:.:..::.:.....|   |.::.|....:   .|.:....:....::..
Human   413 QMTFGERIKN---TISYSLQDYIFQSYWGEWNSYYSKILGRPTTL---CETMGKAEIWLIRTYWD 471

  Fly   261 SEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKHLNPDTVAKM 324
            .|.| ||.:|:...:||:..| ...|||:.:.||: .:..:|.::.||||.|  |:|..:....:
Human   472 FEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKANLI 532

  Fly   325 FNVLSKLKERVIWKWEDQE-NTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHG 388
            .:.|:::.::|:|:::.:: .|.|.:..:.  .|:||:|:|.||..|.||.|.|..||.|:.|||
Human   533 ASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 595

  Fly   389 KPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDR 453
            .||:.:|:|||||.|...|...|..:.::|.|:.......|:..:::.|.|.|.....|.::.|:
Human   596 VPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQ 660

  Fly   454 PMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYR 518
            |:...:..::|.|:|:||.||.||:.....:::...:::|:...:.|.:.:.:.|:.....|..:
Human   661 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQ 725

  Fly   519 RF--ISKPKKEK 528
            :|  |.|.||.:
Human   726 KFGKIGKKKKRE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	112/464 (24%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	125/518 (24%)