Protein Alignment Ugt37A3 and UGT2B11

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001064.1
• Gene: UGT2B11 / 10720
• HGNCID: 12545
• Length: 529
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 137/551 - (24%)
• Similarity: 237/551 - (43%)
• Gaps: 111/551 - (20%)

  Fly    44 SAAKVL---AENGHNVTVVTVLKPVVNH-KNITVI----QVPLSKEEAQQMSDTI--GAMSKNDN 98
            |..|||   ||..|.:.:.|:||.:|.. ..:||:    .:.....:|..:...:  .:::|.:.
Human    22 SCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEF 86

  Fly    99 SNMAL-SLLRMSDQMDFMIRKNAETLMNDR-------VRDLYLN---------------RGNKFD 140
            .|:.: .:.|.||     |||::..|...:       :.|::.|               :.::||
Human    87 ENIIMQQVKRWSD-----IRKDSFWLYFSQEQEILWELYDIFRNFCKDVVSNKKVMKKLQESRFD 146

  Fly   141 LVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLI------------GNPLEVSYAGISNP 193
            :|.:.                     |..|...||..|:            |..:|....|:..|
Human   147 IVFAD---------------------AVFPCGELLAALLNIRFVYSLRFTPGYTIERHSGGLIFP 190

  Fly   194 --------AEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNW---YKEVYGND----PKMPEY 243
                    ::.|..:||..|:.:.:..|.|..:..:|:.  :.|   |.||.|..    ..|.:.
Human   191 PSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDM--KKWDQFYSEVLGRPTTLFETMGKA 253

  Fly   244 SEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSL 307
            ...|...|..|...|     |..|||..   :||...| ...|||:.:.||: .:..:|.::.||
Human   254 DIWLMRNSWSFQFPH-----PFLPNVDF---VGGFHCK-PAKPLPKEMEEFVQSSGENGVVVFSL 309

  Fly   308 G---SNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTP-GKSANILYSKWLPQDDILAHPN 368
            |   ||:..:..|....|     |:|:.::|:|:::.  |.| ....|....||:||:|:|.||.
Human   310 GSVISNMTAERANVIATA-----LAKIPQKVLWRFDG--NKPDALGLNTRLYKWIPQNDLLGHPK 367

  Fly   369 IKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEI 433
            .:.||.|.|..||.|:.|||.||:.:|:|.|||.|...|...|..:.|...|:.......|:..:
Human   368 TRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTV 432

  Fly   434 LSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIC-FL 497
            :::|.|.|.:...|.:..|:|:...:..::|.|:|:.|.||.||:.....:::...:::|:. ||
Human   433 INDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFL 497

  Fly   498 IFVILVSVLVLIKFLVQFIYRRFISKPKKEK 528
            :..:...:.::.||.: |.:.:|..|.||.|
Human   498 LACVATVIFIITKFCL-FCFWKFARKGKKGK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	118/484 (24%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	133/545 (24%)