DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt5f1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_017207383.1	Gene:	ugt5f1 / 100415800	ZFINID:	ZDB-GENE-100406-6	Length:	556	Species:	Danio rerio

Alignment Length:	574	Identity:	144/574 - (25%)
Similarity:	266/574 - (46%)	Gaps:	100/574 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VLRVEKFLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVL---- 62
            ::.|.:.::|::.:....|     .|| :||. ..||.:...:..:.|...||.::|:..|
Zfish    34 IIFVVQIVVLSLTLPVHCG-----KIL-VFPH-EGSHWLNLNTLIEELHHRGHQISVIRALDSWY 91

  Fly    63 ----KPVVNHKNITVI--------------QVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMS 109
                .|..:..|:..:              |:.:.:|:.       ....|.|        :.:.
Zfish    92 IPETSPHYDSINVPFLLGGDDQFYHSFIFRQLQIRREQR-------WTRFKLD--------MELK 141

  Fly   110 DQMDFMIRKNAETLMNDRVRDLYLNRGNK---FDLVISGYFMNDFQLGFARKVNAPVI------- 164
            ::...|.||..|.:::...::..:.:..|   ||::::.. .|...:..|..::.|::
Zfish   142 EKFSEMHRKICEMVIHIVEKEPAIMKQIKEANFDIMLTDP-ANGGGVVLAHYLHLPLVFNVQWTV 205

  Fly   165 ------VLATMPPNHLLNPLIGNPLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHLSE 223
                  .:|..||:::  |.   ||......:|.|......:....||..|.:::|    .|.|.
Zfish   206 HGEAHFAIAPSPPSYV--PF---PLSQLTDSMSFPQRIYNVLFSAVRLFLYRRTVG----PHYSA 261

  Fly   224 RRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLP 288
            ..||     ::|  |.: :|.|:.:...:....:....:.| ||.:|:.|.|||... .....||
Zfish   262 LCNR-----LFG--PGL-DYFELFQAADIWLMRADFVFDFP-RPTMPNVIYIGGFHC-SPAKALP 316

  Fly   289 QNIAEFLGNATD-GAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSANI 352
            :::.:||.::.: |.|::|||:.|  ..|..|...::....::|.::|||::     |..:.||:
Zfish   317 KDLEDFLQSSGEHGVIVMSLGTLV--AQLPMDIADEIVAAFAELPQKVIWRY-----TGDRPANV 374

  Fly   353 ----LYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFG 413
                |...||||:|:|.||..::|::|.|..|:.|:.|||.|::.||:..||..|...|...|..
Zfish   375 GNNTLLVNWLPQNDLLGHPKTRVFVSHGGTNGVFEAIYHGVPIVGLPLVFDQDYNLLKMKHKGVA 439

  Fly   414 LTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQ 478
            ..|.:.|:....|::|:.|:|::|.|...::..|:|::|.|:...:|.|:|||:|:||.|||||:
Zfish   440 KVLDIATINRNIFKDALQEVLNDPSYRSNMQKLSSLHKDTPLKPLDSALFWTEFVMRHRGAAHLR 504

  Fly   479 SPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYR----RFISKPKKEK 528
            :....|.:.:.:::|    :.|.|||||..|.||:..|.|    ||.:|..:.|
Zfish   505 TDSYKMPWYSYHSVD----VGVFLVSVLCFIVFLMFKIVRCLCCRFCAKTNRAK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	128/530 (24%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	136/535 (25%)
ugt5f1	XP_017207383.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840