DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A3 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	578	Identity:	148/578 - (25%)
Similarity:	253/578 - (43%)	Gaps:	119/578 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAIAIGAVMGS-SQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITV- 73
            |.|.:..:.|| ..|..|  |...|..||.:......|.|...||.|.|:.........:|.|.
Zfish    13 LWITVMIIFGSLCDGGKI--LVAPLEGSHWVNMDILIKALHGQGHTVDVIRNTNSWFVKENSTYY 75

  Fly    74 --IQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNA----ETLMNDRVRDLY 132
              |.:|.||...::..:.:                 ::.::|:...|.:    ..|..|..:.:|
Zfish    76 NSITIPDSKGMDEEFVEDV-----------------LTKKIDYERGKGSWLGGVQLFLDVSKAVY 123

  Fly   133 LN---------------------RGNKFDLVI------SGYFMNDFQLGFARKVNAPVI--VLAT 168
            .:                     :..|:||::      :|..:       |.|:..|::  |..|
Zfish   124 ESHKLVCRLITNIFESEDILKALQEKKYDLMLTDPGWGTGIIL-------AHKLKLPMVYNVRWT 181

  Fly   169 MPPNHLLNPLIGN----PLEVSYAGISNPAEGSKAVTFQRRLSSYMQSLGFGVFSHL-----SER 224
            .|..       |:    |..:||..::......|...|||.::         ||.:|     ..|
Zfish   182 TPGE-------GHFDIAPSPMSYIPLTGSGNTDKMSFFQRVIN---------VFYYLLLDFQCSR 230

  Fly   225 RNRNWYKEVYGN--DPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPL 287
            .|...|:.:...  ||.: ::.::|:...|.........|.| ||.:|:.|..||.|. ....||
Zfish   231 FNVPQYQALCDKYFDPPV-DFYKLLQGADLWLMRVDFVFEFP-RPTMPNIIYTGGFQC-TPTKPL 292

  Fly   288 PQNIAEFLGNATD-GAILLSLGSNVQGKHLNPDTV-AKMFNVLSKLKERVIWKWEDQE-NTPGKS 349
            |.::.:|:.::.| |.|::||||.:.   :.||.| :::....::|.::|||::..:: :|.|.
Zfish   293 PHDLEDFMQSSGDHGVIVMSLGSFIS---VLPDYVSSEIAAAFARLPQKVIWRYTGKKPSTLGN- 353

  Fly   350 ANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGL 414
             |.|...|:||.|:|.||..||||.|.|..|:.|:.|||.|::.:|.|.||..|...:...|...
Zfish   354 -NTLLVDWMPQKDLLGHPKTKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAK 417

  Fly   415 TLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQS 479
            .:||..|.|.....||.|:::.|.|...::..|.|:||:|:...:|.::|.|:|:||.|||||::
Zfish   418 IVSLAELGENSLHAAIQEVINEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRT 482

  Fly   480 PLVHMSFIAANNIDICFLIFVILVSVLVLIKFLVQFIYRRFISK--------PKKEKT 529
            ....|.:.:.:::|:.    |.|::|:::      |||..|::.        .:|.||
Zfish   483 ESYKMPWYSYHSVDVS----VTLIAVVLI------FIYSMFVTVRYLCIKCCSRKRKT 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	137/529 (26%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	137/546 (25%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	141/561 (25%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	86/250 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840