DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A3 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	521	Identity:	139/521 - (26%)
Similarity:	240/521 - (46%)	Gaps:	56/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHLIIQMSAAKVLAENGHNVTV-VTVLKPVVNHK-----NITVIQVPLSKEEAQQMSDTIGAMSK 95
            ||.....:..:.|.:..|:||| |....|.|.|.     :..|.:|.:.||||..:......:..
Zfish    31 SHWHNMRAIIEALVDRNHSVTVLVGSSSPTVPHTQKARFDYHVFKVNIEKEEADAVWSDFIYLWM 95

  Fly    96 NDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLY------LNRGNKFDLVISGYFMNDFQLG 154
            |:.:....::..:     |.:.....||.::..:.::      :.|.:.:|::.|...|....|
Zfish    96 NETATKYETVSNI-----FQVMSRFMTLTDEVCKGMFKEDLLQMLRESHYDVLFSDPMMPCSDL- 154

  Fly   155 FARKVNAPVIVLATMPPNHLLNPLIGN-PLEVSYAGISNPAEG-----SKAVTFQRRLSSYMQSL 213
            .|:.:|.|:::.......:....:.|. |...||.    ||..     :..::|..|:.:.:...
Zfish   155 MAQTLNIPLVLSLRATFAYSFERMCGQMPAPPSYV----PAASLRDHLTDRMSFMERVENMLLYF 215

  Fly   214 GFGVFSHL-----SERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVFFSSHAASEGPIRPNVPSAI 273
            ...||..|     .:|    .|.|:.|....|   .|.:....:....::...|.| ||..|:..
Zfish   216 SHDVFFKLYMMFTFDR----IYTEIRGKPTTM---CETMGKADIWLIRTYWDFEYP-RPFPPNFK 272

  Fly   274 EIGGIQIKDKPDPLPQNIAEFLGNATD-GAILLSLGSNVQGKHLNPDTVAKMFNVLSKLKERVIW 337
            .:||:..| ...||.:.:.||:.::.| |.::.||||.:  |:|..:....:...|.::.::|:|
Zfish   273 FVGGLHCK-PAKPLSKEMEEFVQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVW 334

  Fly   338 KWEDQENTPGKSA-NILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPVFADQP 401
            ::..:  ||...| |.....|:||:|:|.||..|.||.|.|..|:.|:.|||.||:.||:|||||
Zfish   335 RYSGK--TPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQP 397

  Fly   402 RNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESFLYWTE 466
            .|...|...|..:.|.:.|||.|...:|:..:|:||.|.|.:...|.::.|:||...:..:||.|
Zfish   398 DNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIE 462

  Fly   467 YVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFL----VQFIYRRFISKPKKE 527
            :|:|:.||.||:.....:|:...:.:|:.    ..|:|:..||.||    ..|::||.:.|.:.|
Zfish   463 FVMRNKGAKHLRVQAHELSWYQYHCLDVA----AFLLSIAALITFLWVKACCFLFRRCVRKTRPE 523

  Fly   528 K 528
            :
Zfish   524 R 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	127/477 (27%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	138/517 (27%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	137/514 (27%)
		REC	<129..>178	CDD:302758	8/49 (16%)
		egt	<254..485	CDD:223071	81/236 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930